LiCl-promoted Amination of β-methoxy Amides (γ-lactones)

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35514391

Authors

Ru Zhao

Bing-Lin Zeng

Wen-Qiang Jia

Hong-Yi Zhao

Long-Ying Shen

Xiao-Jian Wang

Xian-Dao Pan

Affiliations

Soon will be listed here.

Abstract

An efficient and mild method has been developed for the amination of β-methoxy amides (γ-lactones) including natural products michelolide, costunolide and parthenolide derivatives by using lithium chloride in good yields. This reaction is applicable to a wide range of substrates with good functional group tolerance. Mechanism studies show that the reactions undergo a LiCl promoted MeOH elimination from the substrates to form the corresponding α,β-unsaturated intermediates followed by the Michael addition of amines.

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