Nucleophilic Amination of Methoxypyridines by a Sodium Hydride-iodide Composite

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Aug 25

PMID 30141796

Citations 4

Authors

Jia Hao Pang

Atsushi Kaga

Shunsuke Chiba

Affiliations

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Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

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