The EHA Research Roadmap: Hematopoietic Stem Cells and Allotransplantation

Overview

Journal Hemasphere

Publisher Wiley

Specialty Hematology

Date 2022 May 5

PMID 35509429

Authors

Willem Fibbe

Rosa Bernardi

Pierre Charbord

Daniela Krause

Cristina Lo Celso

Simon Mendez-Ferrer

Christine Mummery

Robert Oostendorp

Marc Raaijmakers

Gerard Socie

Frank Staal

Andrea Bacigalupo

Affiliations

Soon will be listed here.

Citing Articles

The Updated European Hematology Association Research Roadmap.

Engert A, Cerisoli F, Cools J Hemasphere. 2022; 6(6):e743.

PMID: 35747849 PMC: 9208884. DOI: 10.1097/HS9.0000000000000743.

References

Mende N, Jolly A, Percin G, Gunther M, Rostovskaya M, Krishnan S . Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs. Blood. 2019; 134(15):1214-1226. DOI: 10.1182/blood.2019000176. View

Falkenburg F, Ruggiero E, Bonini C, Porter D, Miller J, Malard F . Prevention and treatment of relapse after stem cell transplantation by cellular therapies. Bone Marrow Transplant. 2018; 54(1):26-34. DOI: 10.1038/s41409-018-0227-0. View

Schreck C, Istvanffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L . Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med. 2016; 214(1):165-181. PMC: 5206491. DOI: 10.1084/jem.20151414. View

Dumontet E, Pangault C, Roulois D, Desoteux M, Leonard S, Marchand T . Extracellular vesicles shed by follicular lymphoma B cells promote polarization of the bone marrow stromal cell niche. Blood. 2021; 138(1):57-70. DOI: 10.1182/blood.2020008791. View

Cho B, Min G, Park S, Shin S, Yahng S, Jeon Y . WT1 Measurable Residual Disease Assay in Patients With Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation: Optimal Time Points, Thresholds, and Candidates. Biol Blood Marrow Transplant. 2019; 25(10):1925-1932. DOI: 10.1016/j.bbmt.2019.05.033. View

Xuan L, Wang Y, Huang F, Fan Z, Xu Y, Sun J . Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial. Lancet Oncol. 2020; 21(9):1201-1212. DOI: 10.1016/S1470-2045(20)30455-1. View

Abbuehl J, Tatarova Z, Held W, Huelsken J . Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation. Cell Stem Cell. 2017; 21(2):241-255.e6. DOI: 10.1016/j.stem.2017.07.004. View

Ho Y, Del Toro R, Rivera-Torres J, Rak J, Korn C, Garcia-Garcia A . Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging. Cell Stem Cell. 2019; 25(3):407-418.e6. PMC: 6739444. DOI: 10.1016/j.stem.2019.06.007. View

Mangolini M, Gotte F, Moore A, Ammon T, Oelsner M, Lutzny-Geier G . Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia. Nat Commun. 2018; 9(1):3839. PMC: 6155045. DOI: 10.1038/s41467-018-06069-5. View

10.

Choi Y, Son M, Cho H, Ma Y, Lee J, Kang E . Safety and immune cell kinetics after donor natural killer cell infusion following haploidentical stem cell transplantation in children with recurrent neuroblastoma. PLoS One. 2019; 14(12):e0225998. PMC: 6910678. DOI: 10.1371/journal.pone.0225998. View

11.

Haltalli M, Watcham S, Wilson N, Eilers K, Lipien A, Ang H . Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection. Nat Cell Biol. 2020; 22(12):1399-1410. PMC: 7611033. DOI: 10.1038/s41556-020-00601-w. View

12.

Burt R, Dey A, Aref S, Aguiar M, Akarca A, Bailey K . Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress. Blood. 2019; 134(17):1415-1429. PMC: 6856969. DOI: 10.1182/blood.2019001398. View

13.

de Lima M, Porter D, Battiwalla M, Bishop M, Giralt S, Hardy N . Proceedings from the National Cancer Institute's Second International Workshop on the Biology, Prevention, and Treatment of Relapse After Hematopoietic Stem Cell Transplantation: part III. Prevention and treatment of relapse after allogeneic.... Biol Blood Marrow Transplant. 2013; 20(1):4-13. PMC: 3938421. DOI: 10.1016/j.bbmt.2013.08.012. View

14.

Pfeifer H, Wassmann B, Bethge W, Dengler J, Bornhauser M, Stadler M . Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR-ABL1-positive acute lymphoblastic leukemia. Leukemia. 2012; 27(6):1254-62. DOI: 10.1038/leu.2012.352. View

15.

Graf T, Enver T . Forcing cells to change lineages. Nature. 2009; 462(7273):587-94. DOI: 10.1038/nature08533. View

16.

Lovisa F, Zecca M, Rossi B, Campeggio M, Magrin E, Giarin E . Pre- and post-transplant minimal residual disease predicts relapse occurrence in children with acute lymphoblastic leukaemia. Br J Haematol. 2018; 180(5):680-693. DOI: 10.1111/bjh.15086. View

17.

Sora F, di Grazia C, Chiusolo P, Raiola A, Bregante S, Mordini N . Allogeneic Hemopoietic Stem Cell Transplants in Patients with Acute Myeloid Leukemia (AML) Prepared with Busulfan and Fludarabine (BUFLU) or Thiotepa, Busulfan, and Fludarabine (TBF): A Retrospective Study. Biol Blood Marrow Transplant. 2019; 26(4):698-703. DOI: 10.1016/j.bbmt.2019.12.725. View

18.

Fernandez-Garcia M, Lamana M, Hernando-Rodriguez M, Sanchez-Dominguez R, Bueren J, Yanez R . Improved Hematopoietic Gene Therapy in a Mouse Model of Fanconi Anemia Mediated by Mesenchymal Stromal Cells. Hum Gene Ther. 2017; 29(3):327-336. DOI: 10.1089/hum.2017.076. View

19.

Crippa S, Rossella V, Aprile A, Silvestri L, Rivis S, Scaramuzza S . Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity. J Clin Invest. 2019; 129(4):1566-1580. PMC: 6436882. DOI: 10.1172/JCI123191. View

20.

Ramos T, Sanchez-Abarca L, Roson-Burgo B, Redondo A, Rico A, Preciado S . Mesenchymal stromal cells (MSC) from JAK2+ myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis. PLoS One. 2017; 12(8):e0182470. PMC: 5552029. DOI: 10.1371/journal.pone.0182470. View