Suppression of BMP Signaling by PHD2 Deficiency in Pulmonary Arterial Hypertension

Overview

Journal Pulm Circ

Publisher Wiley

Specialty Pulmonary Medicine

Date 2022 May 4

PMID 35506101

Authors

Bin Liu

Dan Yi

Jiakai Pan

Jingbo Dai

Maggie M Zhu

You-Yang Zhao

S Paul Oh

Michael B Fallon

Zhiyu Dai

Affiliations

Soon will be listed here.

Abstract

BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.

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Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension.

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