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Fecal Matter Transplant from Ace2 Overexpressing Mice Counteracts Chronic Hypoxia-induced Pulmonary Hypertension

Overview
Journal Pulm Circ
Publisher Wiley
Specialty Pulmonary Medicine
Date 2022 May 4
PMID 35506083
Authors
Aline C Oliveira
Tao Yang
Jing Li
Ravindra K Sharma
Marianthi K Karas
Andrew J Bryant
Annette D de Kloet
Eric G Krause
Bina Joe
Elaine M Richards
Mohan K Raizada
Affiliations
Soon will be listed here.
Abstract

Recent evidence suggests pulmonary hypertension (PH), a disease of the pulmonary vasculature actually has multiorgan pathophysiology and perhaps etiology. Herein, we demonstrated that fecal matter transplantation from angiotensin-converting enzyme 2 overexpressing mice counteracted the effects of chronic hypoxia to prevent pulmonary hypertension, neuroinflammation, and gut dysbiosis in wild type recipients.

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