Photosensitized Oxidation of Intracellular Targets: Understanding the Mechanisms to Improve the Efficiency of Photodynamic Therapy

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2022 May 3

PMID 35505023

Authors

Thiago Teixeira Tasso

Mauricio S Baptista

Affiliations

Soon will be listed here.

Abstract

The development of improved photosensitizers is a key aspect in the establishment of photodynamic therapy (PDT) as a reliable treatment modality. In this chapter, we discuss how molecular design can lead to photosensitizers with higher selectivity and better efficiency, with focus on the importance of specific intracellular targeting in determining the cell death mechanism and, consequently, the PDT outcome.

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