Role of P38 MAP Kinase in Cancer Stem Cells and Metastasis

Overview

Journal Oncogene

Specialties Molecular Biology
Oncology

Date 2022 May 2

PMID 35501462

Authors

Sriya Kudaravalli

Petra den Hollander

Sendurai A Mani

Affiliations

Soon will be listed here.

Abstract

Therapeutic resistance and metastatic progression are responsible for the majority of cancer mortalities. In particular, the development of resistance is a significant barrier to the efficacy of cancer treatments such as chemotherapy, radiotherapy, targeted therapies, and immunotherapies. Cancer stem cells (CSCs) underlie treatment resistance and metastasis. p38 mitogen-activated protein kinase (p38 MAPK) is downstream of several CSC-specific signaling pathways, and it plays an important role in CSC development and maintenance and contributes to metastasis and chemoresistance. Therefore, the development of therapeutic approaches targeting p38 can sensitize tumors to chemotherapy and prevent metastatic progression.

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