Icariin Controlled Release on a Silk Fibroin/mesoporous Bioactive Glass Nanoparticles Scaffold for Promoting Stem Cell Osteogenic Differentiation

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35496600

Authors

Xiaofeng Shen

Pengfei Yu

Hua Chen

Jiangping Wang

Binjie Lu

Xuefeng Cai

Chun Gu

Guoqiang Liang

Donglin Hao

Qihan Ma

Yuwei Li

Affiliations

Soon will be listed here.

Abstract

The treatment of bone defects caused by various reasons is still a major problem in orthopedic clinical work. Many studies on osteogenic implant materials have used various biologically active factors such as osteogenic inducers, but these biologically active factors have various side effects. Therefore, in this study, silk fibroin (SF) was used as a scaffold material, mesoporous bioactive glass nanoparticles (MBGNs) as a sustained release carrier, and the traditional Chinese drug icariin (ICA) was loaded to promote bone formation. The experiments in this study have proven that SF/MBGNs-ICA scaffolds can successfully load and release ICA for a long time, and the sustained-release ICA can promote the proliferation and differentiation of BMSCs for a long time. This controlled-release ICA organic/inorganic two-component scaffold material is expected to become a new bone grafting solution.

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