Co-crystallization of Antibacterials with Inorganic Salts: Paving the Way to Activity Enhancement

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35494556

Authors

Oleksii Shemchuk

Dario Braga

Fabrizia Grepioni

Raymond J Turner

Affiliations

Soon will be listed here.

Abstract

Co-crystallization of the antibacterial agents proflavine and methyl viologen with the inorganic salts CuCl, CuCl and AgNO results in enhanced antimicrobial activity with respect to the separate components.

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References

de Kraker M, Davey P, Grundmann H . Mortality and hospital stay associated with resistant Staphylococcus aureus and Escherichia coli bacteremia: estimating the burden of antibiotic resistance in Europe. PLoS Med. 2011; 8(10):e1001104. PMC: 3191157. DOI: 10.1371/journal.pmed.1001104. View

Payne D, Gwynn M, Holmes D, Pompliano D . Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov. 2006; 6(1):29-40. DOI: 10.1038/nrd2201. View

Casali L, Mazzei L, Shemchuk O, Honer K, Grepioni F, Ciurli S . Smart urea ionic co-crystals with enhanced urease inhibition activity for improved nitrogen cycle management. Chem Commun (Camb). 2018; 54(55):7637-7640. DOI: 10.1039/c8cc03777a. View

Levy S, Marshall B . Antibacterial resistance worldwide: causes, challenges and responses. Nat Med. 2004; 10(12 Suppl):S122-9. DOI: 10.1038/nm1145. View

Vishweshwar P, McMahon J, Bis J, Zaworotko M . Pharmaceutical co-crystals. J Pharm Sci. 2006; 95(3):499-516. DOI: 10.1002/jps.20578. View

Turner R . Metal-based antimicrobial strategies. Microb Biotechnol. 2017; 10(5):1062-1065. PMC: 5609261. DOI: 10.1111/1751-7915.12785. View

Duggirala N, Perry M, Almarsson O, Zaworotko M . Pharmaceutical cocrystals: along the path to improved medicines. Chem Commun (Camb). 2015; 52(4):640-55. DOI: 10.1039/c5cc08216a. View

Bolton O, Matzger A . Improved stability and smart-material functionality realized in an energetic cocrystal. Angew Chem Int Ed Engl. 2011; 50(38):8960-3. DOI: 10.1002/anie.201104164. View

Brown E, Wright G . Antibacterial drug discovery in the resistance era. Nature. 2016; 529(7586):336-43. DOI: 10.1038/nature17042. View

10.

Sulavik M, Houseweart C, Cramer C, Jiwani N, Murgolo N, Greene J . Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob Agents Chemother. 2001; 45(4):1126-36. PMC: 90435. DOI: 10.1128/AAC.45.4.1126-1136.2001. View

11.

McDonnell G, Russell A . Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999; 12(1):147-79. PMC: 88911. DOI: 10.1128/CMR.12.1.147. View

12.

Harrison J, Turner R, Joo D, Stan M, Chan C, Allan N . Copper and quaternary ammonium cations exert synergistic bactericidal and antibiofilm activity against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008; 52(8):2870-81. PMC: 2493123. DOI: 10.1128/AAC.00203-08. View

13.

Mehra C, Gala R, Kakatkar A, Kumar V, Khurana R, Chatterjee S . Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalix[6]arene functionalized silver nanoparticles. Chem Commun (Camb). 2019; 55(95):14275-14278. DOI: 10.1039/c9cc07378g. View

14.

Lemire J, Harrison J, Turner R . Antimicrobial activity of metals: mechanisms, molecular targets and applications. Nat Rev Microbiol. 2013; 11(6):371-84. DOI: 10.1038/nrmicro3028. View

15.

Rivardo F, Martinotti M, Turner R, Ceri H . The activity of silver against Escherichia coli biofilm is increased by a lipopeptide biosurfactant. Can J Microbiol. 2010; 56(3):272-8. DOI: 10.1139/w10-007. View

16.

Gugala N, Lemire J, Turner R . The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains. J Antibiot (Tokyo). 2017; 70(6):775-780. DOI: 10.1038/ja.2017.10. View

17.

Wainwright M . Acridine-a neglected antibacterial chromophore. J Antimicrob Chemother. 2001; 47(1):1-13. DOI: 10.1093/jac/47.1.1. View

18.

Li X, Bai H, Yang Y, Yoon J, Wang S, Zhang X . Supramolecular Antibacterial Materials for Combatting Antibiotic Resistance. Adv Mater. 2018; 31(5):e1805092. DOI: 10.1002/adma.201805092. View

19.

Theuretzbacher U . Global antibacterial resistance: The never-ending story. J Glob Antimicrob Resist. 2016; 1(2):63-69. DOI: 10.1016/j.jgar.2013.03.010. View

20.

Gugala N, Vu D, Parkins M, Turner R . Specificity in the Susceptibilities of , and Clinical Isolates to Six Metal Antimicrobials. Antibiotics (Basel). 2019; 8(2). PMC: 6627307. DOI: 10.3390/antibiotics8020051. View