Antibacterial Resistance Worldwide: Causes, Challenges and Responses

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2004 Dec 4

PMID 15577930

Citations 1084

Authors

Stuart B Levy

Bonnie Marshall

Affiliations

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Abstract

The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance--the legacy of past decades of antimicrobial use and misuse. Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs.

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