MiRNAs Can Affect Intestinal Epithelial Barrier in Inflammatory Bowel Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 May 2

PMID 35493445

Authors

Xiangjun Xiao

Xiangbing Mao

Daiwen Chen

Bing Yu

Jun He

Hui Yan

Jianping Wang

Affiliations

Soon will be listed here.

Abstract

The most obvious pathological characterization of inflammatory bowel disease (IBD) is intestinal epithelium erosion and severe inflammation invasion. Micro-ribonucleic acids (miRNA or microRNA), single-stranded noncoding RNAs of ~22 nucleotides, have been considered as the potential therapeutic targets in the pathogenesis of IBD. Many previous studies have focused on the mechanisms that miRNAs use to regulate inflammation, immunity, and microorganisms in IBD. The review highlights in detail the findings of miRNAs in the intestinal epithelial barrier of IBD, and focuses on their gene targets, signaling pathways associated with IBD, and some potential therapies. It will be beneficial for the elucidation of the interaction between miRNAs and the intestinal epithelial barrier in IBD and provide a theoretical reference for preventing and treating IBD in the future.

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