Synthesis of α-indolylacrylates As Potential Anticancer Agents Using a Brønsted Acid Ionic Liquid Catalyst and the Butyl Acetate Solvent

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35493022

Authors

Ahmed El-Harairy

Mennatallah Shaheen

Jun Li

YuZhou Wu

Minghao Li

Yanlong Gu

Affiliations

Soon will be listed here.

Abstract

In this study, new α-indolylacrylate derivatives were synthesized by the reaction of 2-substituted indoles with various pyruvates using a Brønsted acid ionic liquid catalyst in butyl acetate solvent. This is the first report on the application of pyruvate compounds for the synthesis of indolylacrylates. The acrylate derivatives could be obtained in good to excellent yields. A preliminary biological evaluation revealed their promising anticancer activity (IC = 9.73 μM for the compound 4l) and indicated that both the indole core and the acrylate moieties are promising for the development of novel anticancer drugs. The Lipinski's rule and Veber's parameters were assessed for the newly synthesized derivatives.

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