Panorama of Bacterial Infections Caused by Epidemic Resistant Strains

Overview

Journal Curr Microbiol

Specialty Microbiology

Date 2022 Apr 30

PMID 35488983

Authors

Joao Victor de Oliveira Santos

Sergio Dias da Costa Junior

Sandrelli Meridiana de Fatima Ramos Dos Santos Medeiros

Iago Dillion Lima Cavalcanti

Jaqueline Barbosa de Souza

Davi Lacerda Coriolano

Wagner Roberto Cirilo da Silva

Maria Helena Menezes Estevam Alves

Isabella Macario Ferro Cavalcanti

Affiliations

Soon will be listed here.

Abstract

Antimicrobial resistance (AMR) represents a critical obstacle to public health worldwide, due to the high incidence of strains resistant to available antibiotic therapies. In recent years, there has been a significant increase in the prevalence of resistant epidemic strains, associated with this, public health authorities have been alarmed about a possible scenario of uncontrolled dissemination of these microorganisms and the difficulty in interrupting their transmission, as nosocomial pathogens with resistance profiles previously considered sporadic. They become frequent bacteria in the community. In addition, therapy for infections caused by these pathogens is based on broad-spectrum antibiotic therapy, which favors an increase in the tolerance of remaining bacterial cells and is commonly associated with a poor prognosis. In this review, we present the current status of epidemic strains of methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococcus (VRE), MDR Mycobacterium tuberculosis, extended-spectrum β-lactamase-producing Enterobacterales (ESBL), Klebsiella pneumoniae carbapenemase (KPC), and-New Delhi Metallo-beta-lactamase-producing Pseudomonas aeruginosa (NDM).

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