In critically ill patients, the occurrence of multidrug-resistant infection is a significant concern, given its ability to acquire multidrug-resistant, form biofilms and secrete toxic effectors. In Brazil, limited data are...

Influence of the addition of gum arabic and xanthan gum in the preparation of sodium alginate microcapsules coated with chitosan hydrochloride on the survival of Lacticaseibacillus rhamnosus GG

Araujo A, de Paula N, de Lima M, Farias Filho L, Dos Santos Silva R, Nogueira M, et al.

Int J Biol Macromol . 2025 Jan; 294:139388. PMID: 39743065

The microencapsulation of Lactocaseibacillus rhamnosus GG in a matrix of sodium alginate, xanthan gum, gum arabic and chitosan hydrochloride is a promising strategy for protecting this probiotic during passage through...

Anti-staphylococcal, antibiofilm and trypanocidal activities of CrataBL encapsulated into liposomes: Lectin with potential against infectious diseases

Almeida Campos L, Costa Junior S, Santos J, Souza Z, da Silva C, Cristovao-Silva A, et al.

Microb Pathog . 2024 Oct; 196:107007. PMID: 39395747

The present study aimed to evaluate the anti-staphylococcal, antibiofilm, cytotoxicity and trypanocidal activity, mechanisms of parasite death and immunomodulatory effect of CrataBL encapsulated into liposomes (CrataBL-Lipo). CrataBL-Lipo were prepared by...

Nanostructures for Delivery of Flavonoids with Antibacterial Potential against

Macedo H, de Oliveira L, de Oliveira D, Lima K, Cavalcanti I, Almeida Campos L

Antibiotics (Basel) . 2024 Sep; 13(9). PMID: 39335017

Flavonoids are secondary metabolites that exhibit remarkable biological activities, including antimicrobial properties against , a pathogen responsible for several serious nosocomial infections. However, oral administration of these compounds faces considerable...

Ceftazidime and Usnic Acid Encapsulated in Chitosan-Coated Liposomes for Oral Administration against Colorectal Cancer-Inducing

de Souza J, de Lacerda Coriolano D, Dos Santos Silva R, Costa Junior S, Almeida Campos L, Cavalcanti I, et al.

Pharmaceuticals (Basel) . 2024 Jun; 17(6). PMID: 38931469

has been associated with the induction of colorectal cancer (CRC). Thus, combined therapy incorporating usnic acid (UA) and antibiotics such as ceftazidime (CAZ), co-encapsulated in liposomes, could be an alternative....

Synthesis of polymeric nanoparticles by double emulsion and pH-driven: encapsulation of antibiotics and natural products for combating Escherichia coli infections

Almeida Campos L, de Souza J, Macedo H, Borges J, de Oliveira D, Cavalcanti I

Appl Microbiol Biotechnol . 2024 May; 108(1):351. PMID: 38819646

The design, development, and obtaining of nanostructured materials, such as polymeric nanoparticles, have garnered interest due to loading therapeutic agents and its broad applicability. Polymeric nanoparticle synthesis employs advanced techniques...

Prevalence of cagA, cagM, vacA and oipA genes in isolates of Helicobacter pylori obtained from hospital patients in Northeast Brazil

Bezerra T, Xavier K, Luz A, Cavalcanti I, de Brito C, Balbino T

Braz J Microbiol . 2024 May; 55(3):2631-2641. PMID: 38802685

Helicobacter pylori is a major cause of gastrointestinal disorders such as chronic gastritis, peptic ulcers, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. It is estimated that around half of...

Antibacterial and Antibiofilm Potential of Bacterial Cellulose Hydrogel Containing Vancomycin against Multidrug-Resistant and

Correia A, Almeida Campos L, Macedo H, de Lacerda Coriolano D, Agreles M, Xavier D, et al.

Biology (Basel) . 2024 May; 13(5). PMID: 38785836

The present study aimed to evaluate the in vitro antibacterial and antibiofilm activity of bacterial cellulose hydrogel produced by sp. (HYDROGEL) containing vancomycin (VAN) against bacterial strains that cause wound...

Incorporation of essential oils in polymeric films for biomedical applications

Borges J, Almeida Campos L, Kretzschmar E, Cavalcanti I

Int J Biol Macromol . 2024 May; 269(Pt 1):132108. PMID: 38710258

Natural and synthetic biodegradable polymers are widely used to obtain more sustainable films with biological, physicochemical, and mechanical properties for biomedical purposes. The incorporation of essential oils (EOs) in polymeric...

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Ceftazidime/Tobramycin Co-Loaded Chitosan-Coated Zein Nanoparticles against Antibiotic-Resistant and Biofilm-Producing and

Almeida Campos L, Neto A, Scavuzzi A, Lopes A, Santos-Magalhaes N, Cavalcanti I

Pharmaceuticals (Basel) . 2024 Mar; 17(3). PMID: 38543106

This study aimed to co-encapsulate ceftazidime and tobramycin in zein nanoparticles coated with chitosan and to characterize and evaluate the antibacterial and antibiofilm activity against antibiotic-resistant and . Zein nanoparticles,...