Comprehensive Role of SARS-CoV-2 Spike Glycoprotein in Regulating Host Signaling Pathway

Overview

Journal J Med Virol

Specialty Microbiology

Date 2022 Apr 30

PMID 35488404

Authors

Shuvomoy Banerjee

Xinyu Wang

Shujuan Du

Caixia Zhu

Yuping Jia

Yuyan Wang

Qiliang Cai

Affiliations

Soon will be listed here.

Abstract

Since the outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, global public health and the economy have suffered unprecedented damage. Based on the increasing related literature, the characteristics and pathogenic mechanisms of the virus, and epidemiological and clinical features of the disease are being rapidly discovered. The spike glycoprotein (S protein), as a key antigen of SARS-CoV-2 for developing vaccines, antibodies, and drug targets, has been shown to play an important role in viral entry, tissue tropism, and pathogenesis. In this review, we summarize the molecular mechanisms of interaction between S protein and host factors, especially receptor-mediated viral modulation of host signaling pathways, and highlight the progression of potential therapeutic targets, prophylactic and therapeutic agents for prevention and treatment of SARS-CoV-2 infection.

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