Protective Effect of MiR-33-5p on the M1/M2 Polarization of Microglia and the Underlying Mechanism

Overview

Journal Bioengineered

Date 2022 Apr 29

PMID 35485294

Authors

Song Chai

Yilan Sheng

Ran Sun

Jieshi He

Lihua Chen

Fei He

Wenhua Chen

Dingying Ma

Bo Yu

Affiliations

Soon will be listed here.

Abstract

This study was aimed to investigate the influence of miR-33-5p on the M1/M2 polarization of microglia and the underlying mechanism. Transcriptome sequencing was performed using microglia from miR-33-5p mimic and control groups. In total, 507 differentially expressed genes, including 314 upregulated genes and 193 downregulated genes, were identified. The subnetwork of module A, which was extracted from the protein-protein interaction networks, mainly contained the downregulated genes. ,and , the members of module-A networks with the highest degrees, possess the potential of being biomarkers of ischemic stroke due to their function in the cell cycle. NFY, a transcription factor, was predicted to have the regulatory relation with nine downregulated genes. Overall, our findings will provide a valuable foundation for genetic mechanisms and treatment studies of ischemic stroke.

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