ETS1 Acts As a Regulator of Human Healthy Aging Via Decreasing Ribosomal Activity

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2022 Apr 27

PMID 35476452

Authors

Fu-Hui Xiao

Qin Yu

Zhi-Li Deng

Ke Yang

Yunshuang Ye

Ming-Xia Ge

Dongjing Yan

Hao-Tian Wang

Xiao-Qiong Chen

Li-Qin Yang

Bin-Yu Yang

Rong Lin

Wen Zhang

Xing-Li Yang

Lei Dong

Yonghan He

Jumin Zhou

Wang-Wei Cai

Ji Li

Qing-Peng Kong

Affiliations

Soon will be listed here.

Abstract

Adaptation to reduced energy production during aging is a fundamental issue for maintaining healthspan or prolonging life span. Currently, however, the underlying mechanism in long-lived people remains poorly understood. Here, we analyzed transcriptomes of 185 long-lived individuals (LLIs) and 86 spouses of their children from two independent Chinese longevity cohorts and found that the ribosome pathway was significantly down-regulated in LLIs. We found that the down-regulation is likely controlled by (ETS proto-oncogene 1), a transcription factor down-regulated in LLIs and positively coexpressed with most ribosomal protein genes (RPGs). Functional assays showed that ETS1 can bind to RPG promoters, while knockdown reduces RPG expression and alleviates cellular senescence in human dermal fibroblast (HDF) and embryonic lung fibroblast (IMR-90) cells. As protein synthesis/turnover in ribosomes is an energy-intensive cellular process, the decline in ribosomal biogenesis governed by in certain female LLIs may serve as an alternative mechanism to achieve energy-saving and healthy aging.

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