Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis

Overview

Journal ChemSusChem

Specialty Chemistry

Date 2022 Apr 26

PMID 35470567

Authors

Robbert van Putten

Natalie S Eyke

Lorenz M Baumgartner

Victor L Schultz

Georgy A Filonenko

Klavs F Jensen

Evgeny A Pidko

Affiliations

Soon will be listed here.

Abstract

Automation and microfluidic tools potentially enable efficient, fast, and focused reaction development of complex chemistries, while minimizing resource- and material consumption. The introduction of automation-assisted workflows will contribute to the more sustainable development and scale-up of new and improved catalytic technologies. Herein, the application of automation and microfluidics to the development of a complex asymmetric hydrogenation reaction is described. Screening and optimization experiments were performed using an automated microfluidic platform, which enabled a drastic reduction in the material consumption compared to conventional laboratory practices. A suitable catalytic system was identified from a library of Ru -diamino precatalysts. In situ precatalyst activation was studied with H/ P nuclear magnetic resonance (NMR), and the reaction was scaled up to multigram quantities in a batch autoclave. These reactions were monitored using an automated liquid-phase sampling system. Ultimately, in less than a week of total experimental time, multigram quantities of the target enantiopure alcohol product were provided by this automation-assisted approach.

Citing Articles

A Slug Flow Platform with Multiple Process Analytics Facilitates Flexible Reaction Optimization.

Wagner F, Sagmeister P, Jusner C, Tampone T, Manee V, Buono F Adv Sci (Weinh). 2024; 11(13):e2308034.

PMID: 38273711 PMC: 10987115. DOI: 10.1002/advs.202308034.

Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis.

van Putten R, Eyke N, Baumgartner L, Schultz V, Filonenko G, Jensen K ChemSusChem. 2022; 15(14):e202200333.

PMID: 35470567 PMC: 9401021. DOI: 10.1002/cssc.202200333.

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