Between a Rock and a Hard Place: Regulation of Mineralization in the Periodontium

Overview

Journal Genesis

Specialties Biology
Molecular Biology

Date 2022 Apr 23

PMID 35460154

Authors

Natalie L Andras

Fatma F Mohamed

Emily Y Chu

Brian L Foster

Affiliations

Soon will be listed here.

Abstract

The periodontium supports and attaches teeth via mineralized and nonmineralized tissues. It consists of two, unique mineralized tissues, cementum and alveolar bone. In between these tissues, lies an unmineralized, fibrous periodontal ligament (PDL), which distributes occlusal forces, nourishes and invests teeth, and harbors progenitor cells for dentoalveolar repair. Many unanswered questions remain regarding periodontal biology. This review will focus on recent research providing insights into one enduring mystery: the precise regulation of the hard-soft tissue borders in the periodontium which define the interfaces of the cementum-PDL-alveolar bone structure. We will focus on advances in understanding the molecular mechanisms that maintain the unmineralized PDL "between a rock and a hard place" by regulating the mineralization of cementum and alveolar bone.

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