Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia: CARE-FH Protocol

Overview

Journal J Pers Med

Date 2022 Apr 23

PMID 35455722

Authors

Laney K Jones

Marc S Williams

Ilene G Ladd

Dylan Cawley

Shuping Ge

Jing Hao

Dina Hassen

Yirui Hu

H Lester Kirchner

Maria Kobylinski

Michael G Lesko

Matthew C Nelson

Alanna K Rahm

David D Rolston

Katrina M Romagnoli

Tyler J Schubert

Timothy C Shuey

Amy C Sturm

Samuel S Gidding

Affiliations

Soon will be listed here.

Abstract

The Collaborative Approach to Reach Everyone with Familial Hypercholesterolemia (CARE-FH) study aims to improve diagnostic evaluation rates for FH at Geisinger, an integrated health delivery system. This clinical trial relies upon implementation science to transition the initial evaluation for FH into primary care, attempting to identify individuals prior to the onset of atherosclerotic cardiovascular disease events. The protocol for the CARE-FH study of this paper is available online. The first phase of the project focuses on trial design, including the development of implementation strategies to deploy evidence-based guidelines. The second phase will study the intervention, rolled out regionally to internal medicine, community medicine, and pediatric care clinicians using a stepped-wedge design, and analyzing data on diagnostic evaluation rates, and implementation, service, and health outcomes.

Citing Articles

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Implementation of a primary-tertiary shared care model to improve the detection of familial hypercholesterolaemia (FH): a mixed methods pre-post implementation study protocol.

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Using implementation science to develop a familial hypercholesterolemia screening program in primary care: The CARE-FH study.

Jones L, Romagnoli K, Schubert T, Clegg K, Kirchner H, Hu Y J Clin Lipidol. 2024; 18(2):e176-e188.

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Designing implementation strategies to improve identification, cascade testing, and management of families with familial hypercholesterolemia: An intervention mapping approach.

Jones L, Calvo E, Campbell-Salome G, Walters N, Brangan A, Rodriguez G Front Health Serv. 2023; 3:1104311.

PMID: 37188259 PMC: 10175779. DOI: 10.3389/frhs.2023.1104311.

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