CD36, a Signaling Receptor and Fatty Acid Transporter That Regulates Immune Cell Metabolism and Fate

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2022 Apr 19

PMID 35438721

Authors

Yiliang Chen

Jue Zhang

Weiguo Cui

Roy L Silverstein

Affiliations

Soon will be listed here.

Abstract

CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and non-immune cells. It functions as both a signaling receptor responding to DAMPs and PAMPs, as well as a long chain free fatty acid transporter. Recent studies have indicated that CD36 can integrate cell signaling and metabolic pathways through its dual functions and thereby influence immune cell differentiation and activation, and ultimately help determine cell fate. Its expression along with its dual functions in both innate and adaptive immune cells contribute to pathogenesis of common diseases, including atherosclerosis and tumor progression, which makes CD36 and its downstream effectors potential therapeutic targets. This review comprehensively examines the dual functions of CD36 in a variety of immune cells, especially macrophages and T cells. We also briefly discuss CD36 function in non-immune cells, such as adipocytes and platelets, which impact the immune system via intercellular communication. Finally, outstanding questions in this field are provided for potential directions of future studies.

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