Application of Fucoidan As Treatment for Cardiovascular and Cerebrovascular Diseases

Overview

Journal Ther Adv Chronic Dis

Publisher Sage Publications

Date 2022 Apr 18

PMID 35432845

Authors

Ke Wang

Xueli Xu

Qiang Wei

Qiong Yang

Jiarui Zhao

Yuan Wang

Xia Li

Kai Ji

Shuliang Song

Affiliations

Soon will be listed here.

Abstract

Fucoidan is a marine polysaccharide. In recent years, fucoidan has attracted wide-scale attention from the pharmaceutical industries due to its diverse biological activities such as lipid-lowering, anti-atherosclerosis, and anticoagulation. This review clarifies the pharmacological effects of fucoidan in the treatment of human cardiovascular and cerebrovascular diseases. Fucoidan exerts a hypolipidemic effect by increasing the reverse transport of cholesterol, inhibiting lipid synthesis, reducing lipid accumulation, and increasing lipid metabolism. Inflammation, anti-oxidation, and so on have a regulatory effect in the process of atherosclerosis endothelial cells, macrophages, smooth muscle cells, and so on; fucoidan can not only prevent thrombosis through anticoagulation and regulate platelet activation, but also promote the dissolution of formed thrombi. Fucoidan has a neuroprotective effect, and also has a positive effect on the prognosis of the cardiovascular and cerebrovascular. The prospects of applying fucoidan in cardio-cerebrovascular diseases are reviewed to provide some theoretical bases and inspirations for its full-scale development and utilization.

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