Dose-Dependent Efficacy of Umbelliferone and Gelatin-Coated ZnO/ZnS Core-Shell Nanoparticles: A Novel Arthritis Agent for Severe Knee Arthritis

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2022 Apr 18

PMID 35432722

Authors

Yongzhi Zheng

Sivalingam Lakshmanan

Affiliations

Soon will be listed here.

Abstract

Rheumatoid arthritis (RA) is a well-known autoimmune disorder that affects 1% of the global population. Zinc (Zn) is crucial for bone homeostasis, when compared with normal human bone, Zn level found to be decreased in RA patients and collagen-induced arthritis (CIA) rats. Notably, Zn-based medicinal products play a prominent role in reducing disease symptoms and acute side effects of patients with bone-related diseases. In this study, we report the clinical efficiency of gelatin- (Gel-) coated ZnO-ZnS core-shell nanoparticles (CSNPs) with umbelliferon (Uf) drug (Uf-Gel-ZnO-ZnS CSNPs) on the normal and CIA-induced Wistar rats. The formed ZnO-ZnS CSNPs are spherical in shape, with an average particle diameter of 150 ± 7 nm. It showed strong cytocompatibility when tested on L929 and foreskin fibroblasts (BJ) cells by MTT assay. While comparing with free Uf, various doses (2.5 and 5 mg) of Uf-Gel-ZnO-ZnS CSNPs showed strong inhibition of CIA by attenuated proinflammatory cytokines such as interleukin-1, IL-6, PEG2, and IL-17. The Uf-Gel-ZnO-ZnS CSNPs show more effectiveness in reducing joint swelling and also increase the level of antioxidant enzymes. In addition, CSNPs significantly reduced the infiltration of inflammatory cells in the knee joint. Thus, the current study concludes that Uf-Gel-ZnO-ZnS CSNPs feasibly reduce the incidence of arthritis in a dose-dependent manner by attenuation of inflammation.

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References

Amara S, Slama I, Omri K, El Ghoul J, El Mir L, Ben Rhouma K . Effects of nanoparticle zinc oxide on emotional behavior and trace elements homeostasis in rat brain. Toxicol Ind Health. 2013; 31(12):1202-9. DOI: 10.1177/0748233713491802. View

Han B, Fang W, Zhao S, Yang Z, Hoang B . Zinc sulfide nanoparticles improve skin regeneration. Nanomedicine. 2020; 29:102263. DOI: 10.1016/j.nano.2020.102263. View

Kummala R, Veliz D, Fang Z, Xu W, Abitbol T, Xu C . Human Dermal Fibroblast Viability and Adhesion on Cellulose Nanomaterial Coatings: Influence of Surface Characteristics. Biomacromolecules. 2020; 21(4):1560-1567. PMC: 7157835. DOI: 10.1021/acs.biomac.0c00107. View

Dalgaard F, Mulder H, Wojdyla D, Lopes R, Held C, Alexander J . Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial. Circulation. 2019; 141(1):10-20. DOI: 10.1161/CIRCULATIONAHA.119.041296. View

Zhao Y, He Z, Wang R, Cai P, Zhang X, Yuan Q . Comparison of the Therapeutic Effects of Gold Nanoclusters and Gold Nanoparticles on Rheumatoid Arthritis. J Biomed Nanotechnol. 2019; 15(11):2281-2290. DOI: 10.1166/jbn.2019.2848. View

Galli S, Tsai M, Piliponsky A . The development of allergic inflammation. Nature. 2008; 454(7203):445-54. PMC: 3573758. DOI: 10.1038/nature07204. View

Marston B, Palanichamy A, Anolik J . B cells in the pathogenesis and treatment of rheumatoid arthritis. Curr Opin Rheumatol. 2010; 22(3):307-15. PMC: 2947313. DOI: 10.1097/BOR.0b013e3283369cb8. View

Jarosz M, Olbert M, Wyszogrodzka G, Mlyniec K, Librowski T . Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling. Inflammopharmacology. 2017; 25(1):11-24. PMC: 5306179. DOI: 10.1007/s10787-017-0309-4. View

Liu J, Feng X, Wei L, Chen L, Song B, Shao L . The toxicology of ion-shedding zinc oxide nanoparticles. Crit Rev Toxicol. 2016; 46(4):348-84. DOI: 10.3109/10408444.2015.1137864. View

10.

Singh A, Biswas A, Shukla A, Maiti P . Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles. Signal Transduct Target Ther. 2019; 4:33. PMC: 6799838. DOI: 10.1038/s41392-019-0068-3. View

11.

Wang C, Zhang R, Wei X, Lv M, Jiang Z . Metalloimmunology: The metal ion-controlled immunity. Adv Immunol. 2020; 145:187-241. DOI: 10.1016/bs.ai.2019.11.007. View

12.

Prasad A . Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health. Front Nutr. 2015; 1:14. PMC: 4429650. DOI: 10.3389/fnut.2014.00014. View

13.

Lavielle M, Puyraimond-Zemmour D, Romand X, Gossec L, Senbel E, Pouplin S . Methods to improve medication adherence in patients with chronic inflammatory rheumatic diseases: a systematic literature review. RMD Open. 2018; 4(2):e000684. PMC: 6088346. DOI: 10.1136/rmdopen-2018-000684. View

14.

Gadeval A, Chaudhari S, Bollampally S, Polaka S, Kalyane D, Sengupta P . Integrated nanomaterials for non-invasive photothermal therapy of rheumatoid arthritis. Drug Discov Today. 2021; 26(10):2315-2328. DOI: 10.1016/j.drudis.2021.04.026. View

15.

Kneilling M, Rocken M . Mast cells: novel clinical perspectives from recent insights. Exp Dermatol. 2009; 18(5):488-96. DOI: 10.1111/j.1600-0625.2009.00860.x. View

16.

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J . Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018; 9(6):7204-7218. PMC: 5805548. DOI: 10.18632/oncotarget.23208. View

17.

Crofford L . Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther. 2013; 15 Suppl 3:S2. PMC: 3891482. DOI: 10.1186/ar4174. View

18.

Hao J, Wang X, Liu F, Han S, Lian J, Jiang Q . Facile Synthesis ZnS/ZnO/Ni(OH) Composites Grown on Ni Foam: A Bifunctional Materials for Photocatalysts and Supercapacitors. Sci Rep. 2017; 7(1):3021. PMC: 5465224. DOI: 10.1038/s41598-017-03200-2. View

19.

Murugan C, Rayappan K, Thangam R, Bhanumathi R, Shanthi K, Vivek R . Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy. Sci Rep. 2016; 6:34053. PMC: 5057072. DOI: 10.1038/srep34053. View

20.

Lemos H, Grespan R, Vieira S, Cunha T, Verri Jr W, Fernandes K . Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009; 106(14):5954-9. PMC: 2667068. DOI: 10.1073/pnas.0812782106. View