Construction of a Magnesium Hydroxide/graphene Oxide/hydroxyapatite Composite Coating on Mg-Ca-Zn-Ag Alloy to Inhibit Bacterial Infection and Promote Bone Regeneration

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2022 Apr 13

PMID 35415306

Authors

Bo Yuan

Hewei Chen

Rui Zhao

Xuangeng Deng

Guo Chen

Xiao Yang

Zhanwen Xiao

Antoniac Aurora

Bita Ana Iulia

Kai Zhang

Xiangdong Zhu

Antoniac Vasile Iulian

Shen Hai

Xingdong Zhang

Affiliations

Soon will be listed here.

Abstract

The improved corrosion resistance, osteogenic activity, and antibacterial ability are the key factors for promoting the large-scale clinical application of magnesium (Mg)-based implants. In the present study, a novel nanocomposite coating composed of inner magnesium hydroxide, middle graphene oxide, and outer hydroxyapatite (Mg(OH)/GO/HA) is constructed on the surface of Mg-0.8Ca-5Zn-1.5Ag by a combined strategy of hydrothermal treatment, electrophoretic deposition, and electrochemical deposition. The results of material characterization and electrochemical corrosion test showed that all the three coatings have high bonding strength, hydrophilicity and corrosion resistance. studies show that Mg(OH) indeed improves the antibacterial activity of the substrate. The next GO and GO/HA coating procedures both promote the osteogenic differentiation of MC3T3-E1 cells and show no harm to the antibacterial activity of Mg(OH) coating, but the latter exhibits the best promoting effect. studies demonstrate that the Mg alloy with the composite coating not only ameliorates osteolysis induced by bacterial invasion but also promotes bone regeneration under both normal and infected conditions. The current study provides a promising surface modification strategy for developing multifunctional Mg-based implants with good corrosion resistance, antibacterial ability and osteogenic activity to enlarge their biomedical applications.

Citing Articles

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