In Vitro Study of the Mesenchymal Stem Cells-conditional Media Role in Skin Wound Healing Process: A Systematic Review

Overview

Journal Int Wound J

Specialties Emergency Medicine
Orthopedics

Date 2022 Apr 12

PMID 35412017

Authors

Mohammad Bagher Heydari

Zahra Ghanbari-Movahed

Maryam Heydari

Mohammad Hosein Farzaei

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stromal cell (MSC)-conditioned medium (CM) offers a potential opportunity in the skin wound healing treatment. In this systematic review, an overview of the knowledge on this topic has been provided. A multistep search of the PubMed, Scopus and Science Direct database has been performed to identify papers on MSCs-conditional media used in skin wound healing. Eligibility checks were performed based upon predefined selection criteria. Of the 485 articles initially identified, consequently, only 96 articles apparently related to MSC-conditional media were initially assessed for eligibility. Finally, the 32 articles, strictly regarding the in vitro use of MSCs-conditional media in skin wounds, were analysed. The information analysed highlights the efficacy of MSCs-conditional media on skin wound healing in vitro models. The outcome of this review may be used to guide pre-clinical and clinical studies on the role of MSCs-conditional media in skin wound healing.

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