Gastroprotective Effects of Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats

Overview

Journal Nutrients

Date 2022 Apr 12

PMID 35406089

Authors

Baoming Tian

Qin Zhao

Haoyong Xing

Jing Xu

Zhenhao Li

Hua Zhu

Kai Yang

Peilong Sun

Ming Cai

Affiliations

Soon will be listed here.

Abstract

is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastroprotective effects on different polysaccharides (GLPs), GLP was separated into three parts with different molecular weights using 100 kDa, 10 kDa, and 1 kDa membranes. The mitigation effects of different GLPs on ethanol-induced acute gastric injury were observed in rats. After pretreatment with different GLPs, especially GLP above 10 kDa, the symptoms of gastric mucosal congestion and bleeding were improved; serum myeloperoxidase, inflammatory factor, and histamine were decreased; and antioxidant activity and defense factors (NO and EGF) were increased. Results showed that GLP with different molecular weights had a dose-dependent effect in alleviating alcohol-induced gastric injury. The underlying mechanism might be related to regulating anti-oxidation, promoting the release of related defense factors, reducing inflammatory factors, and reducing the level of histamine in serum. The current work indicated that GLPs above 10 kDa could be applied as natural resources for producing new functional foods to prevent gastric injury induced by ethanol.

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