Small Nucleolar RNA is Potential As a Novel Player in Leukemogenesis and Clinical Application

Overview

Journal Blood Sci

Date 2022 Apr 11

PMID 35402848

Authors

Li-Min Lin

Qi Pan

Yu-Meng Sun

Wen-Tao Wang

Affiliations

Soon will be listed here.

Abstract

Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis, prognosis, and treatment of leukemia. Research has found that small nuclear RNA (snoRNA) plays an essential role in leukemia. These small non-coding RNAs are involved in ribosome biogenesis, including the 2'-O-methylation and pseudouridylation of precursor ribosomal RNA (pre-rRNA), and pre-rRNA splicing. Recently, many snoRNAs were found to be orphans that have no predictable RNA modification targets, but these RNAs have always been found to be located in different subcellular organelles, and they play diverse roles. Using high-throughput technology, snoRNA expression profiles have been revealed in leukemia, and some of the deregulated snoRNAs may regulate the cell cycle, differentiation, proliferation, and apoptosis in leukemic cells and confer drug resistance during leukemia treatment. In this review, we discuss the expression profiles and functions of snoRNAs, particularly orphan snoRNAs, in leukemia. It is possible that the dysregulated snoRNAs are promising diagnosis and prognosis markers for leukemia, which may serve as potential therapeutic targets in leukemia treatment.

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References

Wang W, Chen T, Zeng Z, Pan Q, Huang W, Han C . The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. J Hematol Oncol. 2020; 13(1):78. PMC: 7302350. DOI: 10.1186/s13045-020-00909-y. View

Kasakovski D, Xu L, Li Y . T cell senescence and CAR-T cell exhaustion in hematological malignancies. J Hematol Oncol. 2018; 11(1):91. PMC: 6032767. DOI: 10.1186/s13045-018-0629-x. View

Pelletier J, Thomas G, Volarevic S . Ribosome biogenesis in cancer: new players and therapeutic avenues. Nat Rev Cancer. 2017; 18(1):51-63. DOI: 10.1038/nrc.2017.104. View

Croce C, Calin G . miRNAs, cancer, and stem cell division. Cell. 2005; 122(1):6-7. DOI: 10.1016/j.cell.2005.06.036. View

Darzacq X, Jady B, Verheggen C, Kiss A, Bertrand E, Kiss T . Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. EMBO J. 2002; 21(11):2746-56. PMC: 126017. DOI: 10.1093/emboj/21.11.2746. View

Ofengand J . Ribosomal RNA pseudouridines and pseudouridine synthases. FEBS Lett. 2002; 514(1):17-25. DOI: 10.1016/s0014-5793(02)02305-0. View

Steinbusch M, Caron M, Surtel D, van den Akker G, van Dijk P, Friedrich F . The antiviral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion. J Biol Chem. 2019; 294(13):5121-5136. PMC: 6442052. DOI: 10.1074/jbc.RA119.007356. View

Ben-Shem A, Garreau de Loubresse N, Melnikov S, Jenner L, Yusupova G, Yusupov M . The structure of the eukaryotic ribosome at 3.0 Å resolution. Science. 2011; 334(6062):1524-9. DOI: 10.1126/science.1212642. View

Yang J, Zhang X, Huang Z, Zhou H, Huang M, Zhang S . snoSeeker: an advanced computational package for screening of guide and orphan snoRNA genes in the human genome. Nucleic Acids Res. 2006; 34(18):5112-23. PMC: 1636440. DOI: 10.1093/nar/gkl672. View

10.

Valleron W, Laprevotte E, Gautier E, Quelen C, Demur C, Delabesse E . Specific small nucleolar RNA expression profiles in acute leukemia. Leukemia. 2012; 26(9):2052-60. DOI: 10.1038/leu.2012.111. View

11.

Michel C, Holley C, Scruggs B, Sidhu R, Brookheart R, Listenberger L . Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab. 2011; 14(1):33-44. PMC: 3138526. DOI: 10.1016/j.cmet.2011.04.009. View

12.

Teittinen K, Laiho A, Uusimaki A, Pursiheimo J, Gyenesei A, Lohi O . Expression of small nucleolar RNAs in leukemic cells. Cell Oncol (Dordr). 2012; 36(1):55-63. DOI: 10.1007/s13402-012-0113-5. View

13.

Schwartz S, Bernstein D, Mumbach M, Jovanovic M, Herbst R, Leon-Ricardo B . Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Cell. 2014; 159(1):148-162. PMC: 4180118. DOI: 10.1016/j.cell.2014.08.028. View

14.

Smith C, Steitz J . Sno storm in the nucleolus: new roles for myriad small RNPs. Cell. 1997; 89(5):669-72. DOI: 10.1016/s0092-8674(00)80247-0. View

15.

Nakamura Y, Takahashi N, Kakegawa E, Yoshida K, Ito Y, Kayano H . The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma. Cancer Genet Cytogenet. 2008; 182(2):144-9. DOI: 10.1016/j.cancergencyto.2008.01.013. View

16.

Scott M, Ono M, Yamada K, Endo A, Barton G, Lamond A . Human box C/D snoRNA processing conservation across multiple cell types. Nucleic Acids Res. 2011; 40(8):3676-88. PMC: 3333852. DOI: 10.1093/nar/gkr1233. View

17.

Li X, Zhou B, Chen L, Gou L, Li H, Fu X . GRID-seq reveals the global RNA-chromatin interactome. Nat Biotechnol. 2017; 35(10):940-950. PMC: 5953555. DOI: 10.1038/nbt.3968. View

18.

Dong X, Rodriguez C, Guo P, Sun X, Talbot J, Zhou W . SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum Mol Genet. 2008; 17(7):1031-42. PMC: 2923223. DOI: 10.1093/hmg/ddm375. View

19.

Mourtada-Maarabouni M, Hedge V, Kirkham L, Farzaneh F, Williams G . Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). J Cell Sci. 2008; 121(Pt 7):939-46. DOI: 10.1242/jcs.024646. View

20.

Wu J, Xiao Y, Sun J, Sun H, Chen H, Zhu Y . A single-cell survey of cellular hierarchy in acute myeloid leukemia. J Hematol Oncol. 2020; 13(1):128. PMC: 7517826. DOI: 10.1186/s13045-020-00941-y. View