Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Apr 11

PMID 35401544

Authors

Neslihan Pakize Tasli

Zeynep Burcin Gonen

Oguz Kaan Kirbas

Nur Seda Gokdemir

Batuhan Turhan Bozkurt

Buse Bayrakci

Derya Sagrac

Ezgi Taskan

Sevda Demir

Nur Ekimci Gurcan

Melike Bayindir Bilgic

Omer Faruk Bayrak

Hazel Yetiskin

Busra Kaplan

Shaikh Terkis Islam Pavel

Gokcen Dinc

Muge Serhatli

Gamze Cakirca

Ahmet Eken

Vedat Aslan

Mehmet Yay

Musa Karakukcu

Ekrem Unal

Fethi Gul

Kemal Erdem Basaran

Yusuf Ozkul

Fikrettin Sahin

Olcay Y Jones

Saban Tekin

Aykut Ozdarendeli

Mustafa Cetin

Affiliations

Soon will be listed here.

Abstract

The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a structural, biochemical, and biological characterization of our proprietary product, convalescent human immune plasma-derived exosome (ChipEXO), following the guidelines set forth by the Turkish Ministry of Health and the Turkish Red Crescent, the Good Manufacturing Practice, the International Society for Extracellular Vesicles, and the Gene Ontology Consortium. The data support the safety and efficacy of this product against SARS-CoV-2 infections in preclinical models.

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