Extracellular Vesicle Therapeutics from Plasma and Adipose Tissue

Overview

Journal Nano Today

Specialty Biotechnology

Date 2021 May 10

PMID 33968157

Citations 24

Authors

Dalila Iannotta

Man Yang

Christian Celia

Luisa Di Marzio

Joy Wolfram

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) are cell-released lipid-bilayer nanoparticles that contain biologically active cargo involved in physiological and pathological intercellular communication. In recent years, the therapeutic potential of EVs has been explored in various disease models. In particular, mesenchymal stromal cell-derived EVs have been shown to exert anti-inflammatory, anti-oxidant, anti-apoptotic, and pro-angiogenic properties in cardiovascular, metabolic and orthopedic conditions. However, a major drawback of EV-based therapeutics is scale-up issues due to extensive cell culture requirements and inefficient isolation protocols. An emerging alternative approach to time-consuming and costly cell culture expansion is to obtain therapeutic EVs directly from the body, for example, from plasma and adipose tissue. This review discusses isolation methods and therapeutic applications of plasma and adipose tissue-derived EVs, highlighting advantages and disadvantages compared to cell culture-derived ones.

Citing Articles

Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p.

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Extracellular vesicles from platelet-poor plasma possess anti-inflammatory and anti-catabolic effects in chondrocytes stimulated with IL-1β or synovial membrane-conditioned media.

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Exosome-based cell therapy for diabetic foot ulcers: Present and prospect.

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Hydrogel Microneedle Patches Loaded with Stem Cell Mitochondria-Enriched Microvesicles Boost the Chronic Wound Healing.

Yao W, Zhou J, Tang C, Zhang J, Chen Z, Li Y ACS Nano. 2024; 18(39):26733-26750.

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Strategies for Small Extracellular Vesicle-Based Cancer Immunotherapy.

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