Monte Carlo Evaluation of Target Dose Coverage in Lung Stereotactic Body Radiation Therapy with Flattening Filter-free Beams

Overview

Journal J Radiother Pract

Publisher Cambridge University Press

Specialty Radiology

Date 2022 Apr 11

PMID 35401050

Authors

Oleg N Vassiliev

Christine B Peterson

Joe Y Chang

Radhe Mohan

Affiliations

Soon will be listed here.

Abstract

Aim: Previous studies showed that replacing conventional flattened beams (FF) with flattening filter-free (FFF) beams improves the therapeutic ratio in lung stereotactic body radiation therapy (SBRT), but these findings could have been impacted by dose calculation uncertainties caused by the heterogeneity of the thoracic anatomy and by respiratory motion, which were particularly high for target coverage. In this study, we minimized such uncertainties by calculating doses using high-spatial-resolution Monte Carlo and four-dimensional computed tomography (4DCT) images. We aimed to evaluate more reliably the benefits of using FFF beams for lung SBRT.

Materials And Methods: For a cohort of 15 patients with early stage lung cancer that we investigated in a previous treatment planning study, we recalculated dose distributions with Monte Carlo using 4DCT images. This included fifteen FF and fifteen FFF treatment plans.

Results: Compared to Monte Carlo, the treatment planning system (TPS) over-predicted doses in low-dose regions of the planning target volume. For most patients, replacing FF beams with FFF beams improved target coverage, tumor control, and uncomplicated tumor control probabilities.

Conclusions: Monte Carlo tends to reveal deficiencies in target coverage compared to coverage predicted by the TPS. Our data support previously reported benefits of using FFF beams for lung SBRT.

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