Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2022 Apr 11

PMID 35399932

Authors

Sho Tano

Tomomi Kotani

Takafumi Ushida

Masato Yoshihara

Kenji Imai

Tomoko Nakano-Kobayashi

Yoshinori Moriyama

Yukako Iitani

Fumie Kinoshita

Shigeru Yoshida

Mamoru Yamashita

Yasuyuki Kishigami

Hidenori Oguchi

Hiroaki Kajiyama

Affiliations

Soon will be listed here.

Abstract

Introduction: Weight change during the interpregnancy is related to gestational diabetes mellitus (GDM) in the subsequent pregnancy. In interpregnancy care/counseling, the timeframe for goal setting is important, while the timing of the next conception is unpredictable and preventing age-related body weight gain is difficult. This study aimed to investigate the association between annual weight gain during the interpregnancy, which provide clearer timeframe, and GDM in subsequent pregnancies.

Methods: This multicenter retrospective study was conducted by collecting data on two pregnancies of the same women in 2009-2019. The association between annual BMI gain and GDM during the subsequent pregnancy was examined.

Results: This study included 1,640 pregnant women. A history of GDM [adjusted odds ratio (aOR), 26.22; 95% confidence interval (CI), 14.93-46.07] and annual BMI gain (aOR, 1.48; 95% CI, 1.22-1.81) were related to GDM during the subsequent pregnancy. In the women with a pre-pregnant BMI of <25.0 kg/m and without GDM during the index pregnancy, an annual BMI gain of ≥0.6 kg/m/year during the interpregnancy were associated with GDM in subsequent pregnancies; however, in the other subgroups, it was not associated with GDM in subsequent pregnancies.

Conclusions: For women with a pre-pregnant BMI of <25.0 kg/m and without GDM during the index pregnancy, maintaining an annual BMI gain of <0.6 kg/m/year may prevent GDM during the subsequent pregnancy.

Citing Articles

Impact of interpregnancy weight change on the risk of gestational diabetes mellitus during a second pregnancy in Chinese population: a retrospective cohort study.

Yang A, Wang Y, Liu Y, Yang J, Xu C, Zhong S BMJ Open. 2025; 15(1):e084282.

PMID: 39855650 PMC: 11758697. DOI: 10.1136/bmjopen-2024-084282.

Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management.

Tano S, Kotani T, Ushida T, Matsuo S, Yoshihara M, Imai K Hypertens Res. 2024; 48(3):884-893.

PMID: 39663391 PMC: 11879865. DOI: 10.1038/s41440-024-02024-8.

Identifying the high-benefit population for weight management-based cardiovascular disease prevention in Japan.

Tano S, Kotani T, Matsuo S, Ushida T, Imai K, Kajiyama H Prev Med Rep. 2024; 43:102782.

PMID: 39026567 PMC: 11257143. DOI: 10.1016/j.pmedr.2024.102782.

Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care.

Kotani T, Tano S, Ushida T, Imai K, Kajiyama H Nagoya J Med Sci. 2024; 86(2):160-168.

PMID: 38962410 PMC: 11219228. DOI: 10.18999/nagjms.86.2.160.

Impact of interpregnancy weight changes and perinatal outcomes: A retrospective study in Japan.

Yamamoto M, Aoki S, Shinoda S, Ishikawa H, Miyagi E PLoS One. 2024; 19(2):e0299794.

PMID: 38421997 PMC: 10903892. DOI: 10.1371/journal.pone.0299794.

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