Effects of Obesity and a History of Gestational Diabetes on the Risk of Postpartum Diabetes and Hyperglycemia in Chinese Women: Obesity, GDM and Diabetes Risk

Overview

Journal Diabetes Res Clin Pract

Specialty Endocrinology

Date 2019 Sep 1

PMID 31472162

Citations 14

Authors

Yuxin Fan

Weiqin Li

Huikun Liu

Leishen Wang

Shuang Zhang

Wei Li

Hongyan Liu

Junhong Leng

Yun Shen

Jaakko Tuomilehto

Zhijie Yu

Xilin Yang

Ming Liu

Gang Hu

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the independent or combined effects of gestational diabetes (GDM) and pre-pregnancy and postpartum BMI on the odds of postpartum diabetes and hyperglycemia.

Methods: The study samples included 1263 women with prior GDM and 705 women without GDM. Postpartum 1-7 years diabetes was diagnosed by the standard oral glucose tolerance test.

Results: The multivariable-adjusted odds ratios among women with prior GDM, compared with those without it, were 7.52 for diabetes and 2.27 for hyperglycemia. The multivariable-adjusted odds ratios at different postpartum BMI levels (<24, 24-27.9, and ≥ 28 kg/m) were 1.00, 2.80, and 8.08 for diabetes (P < 0.001), and 1.00, 2.10, and 4.42 for hyperglycemia (P < 0.001), respectively. Women with high body fat (≥31.9%) or abdominal obesity (≥85 cm) had a 2.7-6.9-fold higher odds ratio for diabetes or hyperglycemia. Women with both obesity and prior GDM had the highest risk of diabetes or hyperglycemia compared with non-obese women without GDM. Non-obese women with prior GDM had the same risk of diabetes and hyperglycemia as non-GDM women with obesity. When using Cox regression models, the results were very close to those using logistic regression models.

Conclusions: Maternal prior GDM and pre-pregnancy or postpartum obesity contribute equally to postpartum diabetes and hyperglycemia risk.

Citing Articles

Impact of pre-pregnancy body mass index on preeclampsia.

Mao J, Sun H, Shen Q, Zou C, Yang Y, Du Q Front Med (Lausanne). 2025; 12:1529966.

PMID: 39975682 PMC: 11835700. DOI: 10.3389/fmed.2025.1529966.

Body mass index trajectories and time in target range after delivery and long-term type 2 diabetes risk in women with a history of gestational diabetes mellitus.

Zhang L, Shen Y, Liu H, Li W, Wang L, Zhang S Diabetes Obes Metab. 2024; 27(1):320-327.

PMID: 39431360 PMC: 11620931. DOI: 10.1111/dom.16020.

Gestational Diabetes Mellitus and Postpartum Hypertension: Evidence for a Tight Linkage Toward Women's Cardiovascular Health.

Shen Y, Hu G Hypertension. 2024; 81(6):1269-1271.

PMID: 38748767 PMC: 11101140. DOI: 10.1161/HYPERTENSIONAHA.124.22919.

Weight Categories, Trajectories, Eating Behavior, and Metabolic Consequences during Pregnancy and Postpartum in Women with GDM.

Schenk S, Ravussin Y, Lacroix A, Quansah D, Puder J Nutrients. 2024; 16(4).

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The Role of Phytochemicals and Plant-Based Diets in Gestational Diabetes: Evidence from Clinical Trials.

Jaworsky K, DeVillez P, Basu A Int J Environ Res Public Health. 2023; 20(5).

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