A Systematic Review and Meta-analysis on the Association Between CD36 Rs1761667 Polymorphism and Cardiometabolic Risk Factors in Adults

Overview

Journal Sci Rep

Specialty Science

Date 2022 Apr 9

PMID 35396566

Authors

Zeinab Yazdanpanah

Hassan Mozaffari-Khosravi

Masoud Mirzaei

Mohammad Hasan Sheikhha

Amin Salehi-Abargouei

Affiliations

Soon will be listed here.

Abstract

The cluster of differentiation 36 (CD36) is one of the main receptors implicated in the pathogenesis of the cardiovascular disease. This study aimed to assess the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors including body mass index (BMI), waist circumference (WC), total cholesterol (TC), triglyceride, HDL-C, LDL-C, blood pressure and fasting blood glucose (FBG). PubMed, EMBASE, Scopus, web of science, and Google Scholar were searched up to December 2021. Subgroup and meta-regression analyses were conducted to explore sources of heterogeneity. Eighteen eligible studies (6317 participants) were included in the study. In the overall analysis, a significant association was found between rs1761667 polymorphism of CD36 and TG in allelic (p < 0.001), recessive (p = 0.001) and homozygous (p = 0.006) models. A relationship between this polymorphism and HDL-C and FBG level was observed in the recessive genetic model. In the subgroup analysis, the A allele was associated with impaired lipid profiles (TC, LDL-C and HDL-C) in the Asian population. The influences of health status, design of the study, confounders, and other sources of heterogeneity should be considered when interpreting present findings. Cohort studies with large sample size and in different ethnicities are needed to confirm the relationship between rs1761667 SNP and cardiometabolic risk factors.

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References

Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C . A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum Mol Genet. 2004; 13(19):2197-205. DOI: 10.1093/hmg/ddh233. View

Momeni-Moghaddam M, Asadikaram G, Akbari H, Abolhassani M, Masoumi M, Nadimy Z . CD36 gene polymorphism rs1761667 (G > A) is associated with hypertension and coronary artery disease in an Iranian population. BMC Cardiovasc Disord. 2019; 19(1):140. PMC: 6560776. DOI: 10.1186/s12872-019-1111-6. View

Li H, Fan J, Zhao Y, Zhang X, Dai B, Zhan J . Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart. Circ Res. 2019; 125(12):1106-1120. PMC: 6903355. DOI: 10.1161/CIRCRESAHA.119.314898. View

Keller K, Liang L, Sakimura J, May D, Van Belle C, Breen C . Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans. Obesity (Silver Spring). 2012; 20(5):1066-73. PMC: 3743670. DOI: 10.1038/oby.2011.374. View

Mrizak I, Sery O, Plesnik J, Arfa A, Fekih M, Bouslema A . The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women. Br J Nutr. 2015; 113(8):1330-7. DOI: 10.1017/S0007114515000343. View

Pascual G, Avgustinova A, Mejetta S, Martin M, Castellanos A, Stephan-Otto Attolini C . Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. 2016; 541(7635):41-45. DOI: 10.1038/nature20791. View

Goldstein J, Hazzard W, Schrott H, Bierman E, Motulsky A . Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. J Clin Invest. 1973; 52(7):1533-43. PMC: 302425. DOI: 10.1172/JCI107331. View

Goddard K, Hopkins P, Hall J, Witte J . Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. Am J Hum Genet. 2000; 66(1):216-34. PMC: 1288328. DOI: 10.1086/302727. View

Solakivi T, Kunnas T, Nikkari S . Contribution of fatty acid transporter (CD36) genetic variant rs1761667 to body mass index, the TAMRISK study. Scand J Clin Lab Invest. 2015; 75(3):254-8. DOI: 10.3109/00365513.2014.1003596. View

10.

Hirano K, Kuwasako T, Nakagawa-Toyama Y, Janabi M, Yamashita S, Matsuzawa Y . Pathophysiology of human genetic CD36 deficiency. Trends Cardiovasc Med. 2003; 13(4):136-41. DOI: 10.1016/s1050-1738(03)00026-4. View

11.

Zhang X, Zhou L, Ban X, Liu D, Jiang W, Liu X . Decreased expression of CD36 in circumvallate taste buds of high-fat diet induced obese rats. Acta Histochem. 2010; 113(6):663-7. DOI: 10.1016/j.acthis.2010.09.007. View

12.

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

13.

Madden J, Carrero J, Brunner A, Dastur N, Shearman C, Calder P . Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men. Prostaglandins Leukot Essent Fatty Acids. 2008; 78(6):327-35. DOI: 10.1016/j.plefa.2008.04.003. View

14.

Brundert M, Heeren J, Merkel M, Carambia A, Herkel J, Groitl P . Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells. J Lipid Res. 2011; 52(4):745-58. PMC: 3284166. DOI: 10.1194/jlr.M011981. View

15.

Choi S, Friso S . Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr. 2011; 1(1):8-16. PMC: 3042783. DOI: 10.3945/an.110.1004. View

16.

Zhang Y, Zang J, Wang B, Li B, Yao X, Zhao H . CD36 genotype associated with ischemic stroke in Chinese Han. Int J Clin Exp Med. 2015; 8(9):16149-57. PMC: 4659017. View

17.

Cinar E, Saxena S, Gagnon I . Differential Effects of Concurrent Tasks on Gait in Typically Developing Children: A Meta-Analysis. J Mot Behav. 2020; 53(4):509-522. DOI: 10.1080/00222895.2020.1791038. View

18.

Boghdady A, Arafa U, Sabet E, Salama E, El Sharawy A, Elbadry M . Association between rs1761667 polymorphism of CD36 gene and risk of coronary atherosclerosis in Egyptian population. Cardiovasc Diagn Ther. 2016; 6(2):120-30. PMC: 4805761. DOI: 10.21037/cdt.2015.12.15. View

19.

Aitman T, Cooper L, Norsworthy P, Wahid F, Gray J, Curtis B . Malaria susceptibility and CD36 mutation. Nature. 2000; 405(6790):1015-6. DOI: 10.1038/35016636. View

20.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M . Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015; 350:g7647. DOI: 10.1136/bmj.g7647. View