Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

Overview

Journal Front Pharmacol

Date 2022 Apr 8

PMID 35392570

Authors

Bin Tu

Yanrong Gao

FeiFei Sun

Mingjie Shi

Yongzhuo Huang

Affiliations

Soon will be listed here.

Abstract

The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME) affect the antitumor responses of immune cells and cause immune evasion. Therefore, targeting lipid metabolism in the TME for enhancing the antitumor effect of immune cells is a promising direction for cancer treatment. Cancer nanomedicine has great potential in regulating tumor metabolism and tumor immunity. This review summarizes the nanotechnology-based strategies for lipid metabolism regulation in the TME for enhanced anticancer immune responses.

Citing Articles

Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy.

Zhang H, Li Y, Huang J, Shen L, Xiong Y Acta Pharm Sin B. 2024; 14(11):4717-4737.

PMID: 39664426 PMC: 11628863. DOI: 10.1016/j.apsb.2024.07.021.

From metabolic byproduct to immune modulator: the role of lactate in tumor immune escape.

Jiang M, Wang Y, Zhao X, Yu J Front Immunol. 2024; 15:1492050.

PMID: 39654883 PMC: 11625744. DOI: 10.3389/fimmu.2024.1492050.

Esophageal cancer risk is influenced by genetically determined blood metabolites.

Deng J, Wu S, Huang Y, Deng Y, Yu K Medicine (Baltimore). 2024; 103(43):e40122.

PMID: 39470544 PMC: 11521038. DOI: 10.1097/MD.0000000000040122.

Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review).

Xu M, Cui Y, Wei S, Cong X, Chen Y, Tian S Int J Mol Med. 2023; 53(2).

PMID: 38063240 PMC: 10760796. DOI: 10.3892/ijmm.2023.5337.

Construction and validation of a prognostic nine-gene signature associated with radiosensitivity in head and neck squamous cell carcinoma.

Lu C, Sun Q, Guo Y, Han X, Zhang M, Liu J Clin Transl Radiat Oncol. 2023; 43:100686.

PMID: 37854672 PMC: 10579965. DOI: 10.1016/j.ctro.2023.100686.

References

Huang B, Song B, Xu C . Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Nat Metab. 2020; 2(2):132-141. DOI: 10.1038/s42255-020-0174-0. View

Fu S, He K, Tian C, Sun H, Zhu C, Bai S . Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells. Nat Commun. 2020; 11(1):438. PMC: 6978340. DOI: 10.1038/s41467-020-14332-x. View

Solinas G, Germano G, Mantovani A, Allavena P . Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol. 2009; 86(5):1065-73. DOI: 10.1189/jlb.0609385. View

Wan H, Xu B, Zhu N, Ren B . PGC-1α activator-induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer. Tumori. 2019; 106(1):55-63. DOI: 10.1177/0300891619868287. View

Chimento A, Casaburi I, Avena P, Trotta F, De Luca A, Rago V . Cholesterol and Its Metabolites in Tumor Growth: Therapeutic Potential of Statins in Cancer Treatment. Front Endocrinol (Lausanne). 2019; 9:807. PMC: 6348274. DOI: 10.3389/fendo.2018.00807. View

Hao M, Hou S, Li W, Li K, Xue L, Hu Q . Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy. Sci Transl Med. 2020; 12(571). DOI: 10.1126/scitranslmed.aaz6667. View

Sun B, Hyun H, Li L, Wang A . Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment. Acta Pharmacol Sin. 2020; 41(7):970-985. PMC: 7470849. DOI: 10.1038/s41401-020-0424-4. View

Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca E, Paniccia A . The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J Exp Med. 2013; 210(9):1711-28. PMC: 3754872. DOI: 10.1084/jem.20130440. View

Bian X, Liu R, Meng Y, Xing D, Xu D, Lu Z . Lipid metabolism and cancer. J Exp Med. 2021; 218(1). PMC: 7754673. DOI: 10.1084/jem.20201606. View

10.

Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M . Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood. 2007; 109(9):3812-9. DOI: 10.1182/blood-2006-07-035972. View

11.

Liu X, Hoft D, Peng G . Tumor microenvironment metabolites directing T cell differentiation and function. Trends Immunol. 2022; 43(2):132-147. PMC: 8810659. DOI: 10.1016/j.it.2021.12.004. View

12.

Chalmin F, Bruchard M, Vegran F, Ghiringhelli F . Regulation of T cell antitumor immune response by tumor induced metabolic stress. Cell Stress. 2019; 3(1):9-18. PMC: 6551678. DOI: 10.15698/cst2019.01.171. View

13.

Peng L, Yang H, Ye Y, Ma Z, Kuhn C, Rahmeh M . Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions. Int J Mol Sci. 2021; 22(1). PMC: 7795665. DOI: 10.3390/ijms22010433. View

14.

Monroy-Ramirez H, Galicia-Moreno M, Sandoval-Rodriguez A, Meza-Rios A, Santos A, Armendariz-Borunda J . PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases. Int J Mol Sci. 2021; 22(15). PMC: 8347792. DOI: 10.3390/ijms22158298. View

15.

Niu Z, Shi Q, Zhang W, Shu Y, Yang N, Chen B . Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs. Nat Commun. 2017; 8(1):766. PMC: 5626701. DOI: 10.1038/s41467-017-00523-6. View

16.

Pavlova N, Thompson C . The Emerging Hallmarks of Cancer Metabolism. Cell Metab. 2016; 23(1):27-47. PMC: 4715268. DOI: 10.1016/j.cmet.2015.12.006. View

17.

Baek A, Yu Y, He S, Wardell S, Chang C, Kwon S . The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nat Commun. 2017; 8(1):864. PMC: 5636879. DOI: 10.1038/s41467-017-00910-z. View

18.

Wang W, Bai L, Li W, Cui J . The Lipid Metabolic Landscape of Cancers and New Therapeutic Perspectives. Front Oncol. 2020; 10:605154. PMC: 7753360. DOI: 10.3389/fonc.2020.605154. View

19.

Florance I, Ramasubbu S, Mukherjee A, Chandrasekaran N . Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro. Toxicology. 2021; 458:152850. DOI: 10.1016/j.tox.2021.152850. View

20.

Dou F, Chen J, Cao H, Jia Q, Shen D, Liu T . Anti-atherosclerotic effects of LXRα agonist through induced conversion of M1 macrophage to M2. Am J Transl Res. 2019; 11(6):3825-3840. PMC: 6614608. View