Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Jan 7

PMID 33406768

Citations 19

Authors

Lin Peng

Huixia Yang

Yao Ye

Zhi Ma

Christina Kuhn

Martina Rahmeh

Sven Mahner

Antonis Makrigiannakis

Udo Jeschke

Viktoria von Schonfeldt

Affiliations

Soon will be listed here.

Abstract

Peroxisome proliferator-activated receptors (PPARα, PPAR, and PPAR) belong to the transcription factor family, and they are highly expressed in all types of trophoblast during pregnancy. The present review discusses currently published papers that are related to the regulation of PPARs via lipid metabolism, glucose metabolism, and amino acid metabolism to affect trophoblast physiological conditions, including differentiation, maturation, secretion, fusion, proliferation, migration, and invasion. Recent pieces of evidence have proven that the dysfunctions of PPARs in trophoblast lead to several related pregnancy diseases such as recurrent miscarriage, preeclampsia, intrauterine growth restriction, and gestational diabetes mellitus. Moreover, the underlying mechanisms of PPARs in the control of these processes have been discussed as well. Finally, this review's purposes are to provide more knowledge about the role of PPARs in normal and disturbed pregnancy with trophoblast, so as to find PPAR ligands as a potential therapeutic target in the treatment and prevention of adverse pregnancy outcomes.

Citing Articles

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