Engineering Organ-on-a-chip Systems to Model Viral Infections

Overview

Journal Biofabrication

Date 2022 Apr 7

PMID 35390777

Authors

Fahimeh Shahabipour

Sandro Satta

Mahboobeh Mahmoodi

Argus Sun

Natan Roberto de Barros

Song Li

Tzung Hsiai

Nureddin Ashammakhi

Affiliations

Soon will be listed here.

Abstract

Infectious diseases remain a public healthcare concern worldwide. Amidst the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, increasing resources have been diverted to investigate therapeutics targeting the COVID-19 spike glycoprotein and to develop various classes of vaccines. Most of the current investigations employ two-dimensional (2D) cell culture and animal models. However, 2D culture negates the multicellular interactions and three-dimensional (3D) microenvironment, and animal models cannot mimic human physiology because of interspecies differences. On the other hand, organ-on-a-chip (OoC) devices introduce a game-changer to model viral infections in human tissues, facilitating high-throughput screening of antiviral therapeutics. In this context, this review provides an overview of theOoC-based modeling of viral infection, highlighting the strengths and challenges for the future.

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