Genomic Imprinting in the New Omics Era: A Model for Systems-Level Approaches

Overview

Journal Front Genet

Date 2022 Apr 4

PMID 35368671

Authors

Jean-Noel Hubert

Julie Demars

Affiliations

Soon will be listed here.

Abstract

Genomic imprinting represents a noteworthy inheritance mechanism leading to allele-specific regulations dependent of the parental origin. Imprinted loci are especially involved in essential mammalian functions related to growth, development and behavior. In this mini-review, we first offer a summary of current representations associated with genomic imprinting through key results of the three last decades. We then outline new perspectives allowed by the spread of new omics technologies tackling various interacting levels of imprinting regulations, including genomics, transcriptomics and epigenomics. We finally discuss the expected contribution of new omics data to unresolved big questions in the field.

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