Rs4880 and Rs1050450 Polymorphisms Do Not Confer Risk of COVID-19, but Influence Inflammation or Coagulation Parameters in Serbian Cohort

Overview

Journal Redox Rep

Specialties Biochemistry
Biology
Endocrinology

Date 2022 Apr 1

PMID 35361071

Authors

Djurdja Jerotic

Jovan Ranin

Zoran Bukumiric

Tatjana Djukic

Vesna Coric

Ana Savic-Radojevic

Nevena Todorovic

Milika Asanin

Marko Ercegovac

Ivana Milosevic

Marija Pljesa-Ercegovac

Goran Stevanovic

Marija Matic

Tatjana Simic

Affiliations

Soon will be listed here.

Abstract

Due to the role of oxidative stress in the pathophysiology of COVID-19, it is biologically plausible that inter-individual differences in patients' clinical manifestations might be affected by antioxidant genetic profile. The aim of our study was to assess the distribution of antioxidant genetic polymorphisms rs6721961, rs4880, rs1050450, rs8177412, and (rs1695 and rs1138272) haplotype in COVID-19 patients and controls, with special emphasis on their association with laboratory biochemical parameters. The antioxidant genetic polymorphisms were assessed by appropriate PCR methods in 229 COVID-19 patients and 229 matched healthy individuals. Among examined polymorphisms, only haplotype was associated with COVID-19 risk ( = 0.009). Polymorphisms of and influenced COVID-19 patients' laboratory biochemical profile: *Val allele was associated with increased levels of fibrinogen ( = 0.040) and ferritin ( = 0.033), whereas *Leu allele was associated with D-dimmer ( = 0.009). Our findings regarding the influence of and polymorphisms on inflammation and coagulation parameters might be of clinical importance. If confirmed in larger cohorts, these developments could provide a more personalized approach for better recognition of patients prone to thrombosis and those for the need of targeted antiox-idant therapy.

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