Microbiota-microglia Connections in Age-related Cognition Decline

Overview

Journal Aging Cell

Specialties Cell Biology
Geriatrics

Date 2022 Mar 29

PMID 35349746

Authors

Rui Zhou

Shufang Qian

William C S Cho

Jinyun Zhou

Chentao Jin

Yan Zhong

Jing Wang

Xiaohui Zhang

Zhoujiao Xu

Mei Tian

Lawrence W C Chan

Hong Zhang

Affiliations

Soon will be listed here.

Abstract

Aging is an inevitable process that all individuals experience, of which the extent differs among individuals. It has been recognized as the risk factor of neurodegenerative diseases by affecting gut microbiota compositions, microglia, and cognition abilities. Aging-induced changes in gut microbiota compositions have a critical role in orchestrating the morphology and functions of microglia through the gut-brain axis. Gut microbiota communicates with microglia by its secreted metabolites and neurotransmitters. This is highly associated with age-related cognitive declines. Here, we review the main composition of microbiota in the aged individuals, outline the changes of the brain in age-related cognitive decline from a neuroinflammation perspective, especially the changes of morphology and functions of microglia, discuss the crosstalk between microbiota and microglia in the aged brain and further highlight the role of microbiota-microglia connections in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease).

Citing Articles

The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms.

Guerreiro Diniz D, Bento-Torres J, da Costa V, Carvalho J, Tomas A, Galdino de Oliveira T Int J Mol Sci. 2024; 25(19).

PMID: 39409085 PMC: 11476792. DOI: 10.3390/ijms251910757.

Gut microbiota-derived acetate promotes long-term recovery through angiogenesis guided by lymphatic ingrowth in older adults with stroke.

Yuan Y, Li L, Wang J, Myagmar B, Gao Y, Wang H Front Neurosci. 2024; 18:1398913.

PMID: 39371609 PMC: 11450648. DOI: 10.3389/fnins.2024.1398913.

Exploring the pathogenesis of insomnia and acupuncture intervention strategies based on the microbiota-gut-brain axis.

Guo J, Guo J, Rao X, Zhang R, Li Q, Zhang K Front Microbiol. 2024; 15:1456848.

PMID: 39364160 PMC: 11446747. DOI: 10.3389/fmicb.2024.1456848.

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline.

Zhang L, Wei J, Liu X, Li D, Pang X, Chen F Neural Regen Res. 2024; 20(4):990-1008.

PMID: 38989933 PMC: 11438350. DOI: 10.4103/NRR.NRR-D-23-01776.

Diet Mediate the Impact of Host Habitat on Gut Microbiome and Influence Clinical Indexes by Modulating Gut Microbes and Serum Metabolites.

Zhang J, Qi H, Li M, Wang Z, Jia X, Sun T Adv Sci (Weinh). 2024; 11(19):e2310068.

PMID: 38477427 PMC: 11109649. DOI: 10.1002/advs.202310068.

References

Nagpal R, Neth B, Wang S, Craft S, Yadav H . Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment. EBioMedicine. 2019; 47:529-542. PMC: 6796564. DOI: 10.1016/j.ebiom.2019.08.032. View

Vogt N, Kerby R, Dill-McFarland K, Harding S, Merluzzi A, Johnson S . Gut microbiome alterations in Alzheimer's disease. Sci Rep. 2017; 7(1):13537. PMC: 5648830. DOI: 10.1038/s41598-017-13601-y. View

Moreno-Valladares M, Moreno-Cugnon L, Silva T, Garces J, Saenz-Antonanzas A, Alvarez-Satta M . CD8 T cells are increased in the subventricular zone with physiological and pathological aging. Aging Cell. 2020; 19(9):e13198. PMC: 7511866. DOI: 10.1111/acel.13198. View

Griciuc A, Serrano-Pozo A, Parrado A, Lesinski A, Asselin C, Mullin K . Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013; 78(4):631-43. PMC: 3706457. DOI: 10.1016/j.neuron.2013.04.014. View

Ronchi G, Ryu V, Fornaro M, Czaja K . Hippocampal plasticity after a vagus nerve injury in the rat. Neural Regen Res. 2015; 7(14):1055-63. PMC: 4340018. DOI: 10.3969/j.issn.1673-5374.2012.14.003. View

Lee C, Landreth G . The role of microglia in amyloid clearance from the AD brain. J Neural Transm (Vienna). 2010; 117(8):949-60. PMC: 3653296. DOI: 10.1007/s00702-010-0433-4. View

Gill R, Saksena S, Alrefai W, Sarwar Z, Goldstein J, Carroll R . Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol. 2005; 289(4):C846-52. DOI: 10.1152/ajpcell.00112.2005. View

Vijay-Kumar M, Aitken J, Carvalho F, Cullender T, Mwangi S, Srinivasan S . Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science. 2010; 328(5975):228-31. PMC: 4714868. DOI: 10.1126/science.1179721. View

Abdel-Haq R, Schlachetzki J, Glass C, Mazmanian S . Microbiome-microglia connections via the gut-brain axis. J Exp Med. 2018; 216(1):41-59. PMC: 6314531. DOI: 10.1084/jem.20180794. View

10.

Farber K, Kettenmann H . Functional role of calcium signals for microglial function. Glia. 2006; 54(7):656-665. DOI: 10.1002/glia.20412. View

11.

Henry C, Huang Y, Wynne A, Godbout J . Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav Immun. 2008; 23(3):309-17. PMC: 2692986. DOI: 10.1016/j.bbi.2008.09.002. View

12.

Tahara K, Kim H, Jin J, Maxwell J, Li L, Fukuchi K . Role of toll-like receptor signalling in Abeta uptake and clearance. Brain. 2006; 129(Pt 11):3006-19. PMC: 2445613. DOI: 10.1093/brain/awl249. View

13.

Kim J, Kirkland R, Lee S, Cawthon C, Rzepka K, Minaya D . Gut microbiota composition modulates inflammation and structure of the vagal afferent pathway. Physiol Behav. 2020; 225:113082. PMC: 7484462. DOI: 10.1016/j.physbeh.2020.113082. View

14.

Tan J, McKenzie C, Potamitis M, Thorburn A, Mackay C, Macia L . The role of short-chain fatty acids in health and disease. Adv Immunol. 2014; 121:91-119. DOI: 10.1016/B978-0-12-800100-4.00003-9. View

15.

Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E . Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010; 5(5):e10667. PMC: 2871786. DOI: 10.1371/journal.pone.0010667. View

16.

Zhang H, Sparks J, Karyala S, Settlage R, Luo X . Host adaptive immunity alters gut microbiota. ISME J. 2014; 9(3):770-81. PMC: 4331585. DOI: 10.1038/ismej.2014.165. View

17.

Breen M, Bierer L, Daskalakis N, Bader H, Makotkine I, Chattopadhyay M . Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Transl Psychiatry. 2020; 10(1):1. PMC: 7026151. DOI: 10.1038/s41398-019-0665-5. View

18.

Nguyen P, Dorman L, Pan S, Vainchtein I, Han R, Nakao-Inoue H . Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity. Cell. 2020; 182(2):388-403.e15. PMC: 7497728. DOI: 10.1016/j.cell.2020.05.050. View

19.

Dinan T, Cryan J . Gut-brain axis in 2016: Brain-gut-microbiota axis - mood, metabolism and behaviour. Nat Rev Gastroenterol Hepatol. 2017; 14(2):69-70. DOI: 10.1038/nrgastro.2016.200. View

20.

Makivuokko H, Tiihonen K, Tynkkynen S, Paulin L, Rautonen N . The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition. Br J Nutr. 2009; 103(2):227-34. DOI: 10.1017/S0007114509991553. View