Aging Microglia

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2023 Apr 20

PMID 37081238

Authors

Ignazio Antignano

Yingxiao Liu

Nina Offermann

Melania Capasso

Affiliations

Soon will be listed here.

Abstract

Microglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated. Given the critical role played by microglia in neurodegenerative diseases, a better understanding of the aging microglia phenotype is an essential prerequisite in designing better preventive and therapeutic strategies. In this review, we discuss the most recent literature on microglia in aging, comparing findings in rodent models and human subjects.

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