Blockage of MLKL Prevents Myelin Damage in Experimental Diabetic Neuropathy

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2022 Mar 28

PMID 35344427

Authors

Jia Guo

Zehui Guo

Yanju Huang

Suchen Ma

Bo Yan

Chenjie Pan

Zhaodi Jiang

Fengchao Wang

Zhiyuan Zhang

Yuwei Da

Xiaodong Wang

Zhengxin Ying

Affiliations

Soon will be listed here.

Abstract

SignificanceDiabetic neuropathy is a commonly occurring complication of diabetes that affects hundreds of millions of patients worldwide. Patients suffering from diabetic neuropathy experience abnormal sensations and have damage in their peripheral nerve axons as well as myelin, a tightly packed Schwann cell sheath that wraps around axons to provide insulation and increases electrical conductivity along the nerve fibers. The molecular events underlying myelin damage in diabetic neuropathy are largely unknown, and there is no efficacious treatment for the disease. The current study, using a diabetic mouse model and human patient nerve samples, uncovered a molecular mechanism underlying myelin sheath damage in diabetic neuropathy and provides a potential treatment strategy for the disease.

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