Streptozotocin-Induced Diabetic Models in Mice and Rats

Overview

Journal Curr Protoc Pharmacol

Publisher Wiley

Specialties Biochemistry
Pharmacology

Date 2015 Sep 3

PMID 26331889

Citations 441

Authors

Brian L Furman

Affiliations

Soon will be listed here.

Abstract

Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.

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