Atropoenantioselective Palladaelectro-catalyzed Anilide C-H Olefinations Viable with Natural Sunlight As Sustainable Power Source

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Mar 28

PMID 35340853

Authors

Johanna Frey

Xiaoyan Hou

Lutz Ackermann

Affiliations

Soon will be listed here.

Abstract

Enantioselective electrocatalyzed transformations represent a major challenge. We herein achieved atropoenantioselective pallada-electrocatalyzed C-H olefinations and C-H allylations with high efficacy and enantioselectivity under exceedingly mild reaction conditions. With ()-5-oxoproline as the chiral ligand, activated and non-activated olefins were suitable substrates for the electro-C-H activations. Dual catalysis was devised in terms of electro-C-H olefination, along with catalytic hydrogenation. Challenging enantiomerically-enriched chiral anilide scaffolds were thereby obtained with high levels of enantio-control in the absence of toxic and cost-intensive silver salts. The resource-economy of the transformation was even improved by directly employing renewable solar energy.

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