Advances in HIV-1 Assembly

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2022 Mar 26

PMID 35336885

Authors

Grigoriy Lerner

Nicholas Weaver

Boris Anokhin

Paul Spearman

Affiliations

Soon will be listed here.

Abstract

The assembly of HIV-1 particles is a concerted and dynamic process that takes place on the plasma membrane of infected cells. An abundance of recent discoveries has advanced our understanding of the complex sequence of events leading to HIV-1 particle assembly, budding, and release. Structural studies have illuminated key features of assembly and maturation, including the dramatic structural transition that occurs between the immature Gag lattice and the formation of the mature viral capsid core. The critical role of inositol hexakisphosphate (IP6) in the assembly of both the immature and mature Gag lattice has been elucidated. The structural basis for selective packaging of genomic RNA into virions has been revealed. This review will provide an overview of the HIV-1 assembly process, with a focus on recent advances in the field, and will point out areas where questions remain that can benefit from future investigation.

Citing Articles

Involvement of Human Cellular Proteins and Structures in Realization of the HIV Life Cycle: A Comprehensive Review, 2024.

Schemelev A, Davydenko V, Ostankova Y, Reingardt D, Serikova E, Zueva E Viruses. 2024; 16(11).

PMID: 39599797 PMC: 11599013. DOI: 10.3390/v16111682.

HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1.

Serrano T, Casartelli N, Ghasemi F, Wioland H, Cuvelier F, Salles A Proc Natl Acad Sci U S A. 2024; 121(48):e2407835121.

PMID: 39556735 PMC: 11621841. DOI: 10.1073/pnas.2407835121.

HIV-1 Gag Polyprotein Affinity to the Lipid Membrane Is Independent of Its Surface Charge.

Denieva Z, Sokolov V, Batishchev O Biomolecules. 2024; 14(9).

PMID: 39334852 PMC: 11429625. DOI: 10.3390/biom14091086.

Help or Hinder: Protein Host Factors That Impact HIV-1 Replication.

Moezpoor M, Stevenson M Viruses. 2024; 16(8).

PMID: 39205255 PMC: 11360189. DOI: 10.3390/v16081281.

HIV-1 RNA genome packaging: it's G-rated.

Duchon A, Hu W mBio. 2024; 15(4):e0086123.

PMID: 38411060 PMC: 11005445. DOI: 10.1128/mbio.00861-23.

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