Innate Immune Response in SARS-CoV-2 Infection

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Mar 26

PMID 35336077

Authors

Giovanna Schiuma

Silvia Beltrami

Daria Bortolotti

Sabrina Rizzo

Roberta Rizzo

Affiliations

Soon will be listed here.

Abstract

An efficient host immune response is crucial in controlling viral infections. Despite most studies focused on the implication of T and B cell response in COVID-19 (Corona Virus Disease-19) patients or in their activation after vaccination against SARS-CoV-2, host innate immune response has raised even more interest as well. In fact, innate immunity, including Natural Killer (NK) cells, monocytes/macrophages and neutrophils, represent the first line of defense against the virus and it is essential to determine the correct activation of an efficient and specific acquired immune response. In this perspective, we will report an overview on the main findings concerning SARS-CoV-2 interaction with innate host immune system, in correlation with pathogenesis and viral immune escape mechanisms.

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