Overcoming Multidrug Resistance of Antibiotics Via Nanodelivery Systems

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2022 Mar 26

PMID 35335962

Authors

Mohammad Imran

Saurav Kumar Jha

Nazeer Hasan

Areeba Insaf

Jitendra Shrestha

Jesus Shrestha

Hari Prasad Devkota

Salman Khan

Nisha Panth

Majid Ebrahimi Warkiani

Kamal Dua

Philip M Hansbro

Keshav Raj Paudel

Yousuf Mohammed

Affiliations

Soon will be listed here.

Abstract

Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections. Therefore, to overcome such complications, novel drug delivery systems have gained pharmaceutical scientists' interest. Significant findings have validated the effectiveness of novel drug delivery systems such as polymeric nanoparticles, liposomes, metallic nanoparticles, dendrimers, and lipid-based nanoparticles against severe microbial infections and combating antimicrobial resistance. This review article comprises the specific mechanism of antibiotic resistance development in bacteria. In addition, the manuscript incorporated the advanced nanotechnological approaches with their mechanisms, including interaction with the bacterial cell wall, inhibition of biofilm formations, activation of innate and adaptive host immune response, generation of reactive oxygen species, and induction of intracellular effect to fight against antibiotic resistance. A section of this article demonstrated the findings related to the development of delivery systems. Lastly, the role of microfluidics in fighting antimicrobial resistance has been discussed. Overall, this review article is an amalgamation of various strategies to study the role of novel approaches and their mechanism to fight against the resistance developed to the antimicrobial therapies.

Citing Articles

Multifunctional hyaluronic acid-based biomimetic/pH-responsive hybrid nanostructured lipid carriers for treating bacterial sepsis.

Elhassan E, Omolo C, Gafar M, Ismail E, Ibrahim U, Khan R J Biomed Sci. 2025; 32(1):19.

PMID: 39930418 PMC: 11812216. DOI: 10.1186/s12929-024-01114-6.

Antibiotics' resistance profile of pathogens isolated from fish products sold in the city of Bangangté, Cameroon: Aqueous extracts from spices' formulations used as accompanying soup of braised fish as antimicrobial alternative.

Mouafo H, Pahane M, Nana P, Tsabet H, Sokamte A, Noumo T Heliyon. 2024; 10(23):e40716.

PMID: 39687158 PMC: 11647803. DOI: 10.1016/j.heliyon.2024.e40716.

Antimicrobial Peptide Delivery Systems as Promising Tools Against Resistant Bacterial Infections.

Sampaio de Oliveira K, Leite M, Melo N, Lima L, Barbosa T, Carmo N Antibiotics (Basel). 2024; 13(11).

PMID: 39596736 PMC: 11591436. DOI: 10.3390/antibiotics13111042.

Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers.

Kesharwani P, Halwai K, Jha S, Mughram M, Salman Almujri S, Almalki W Mol Cancer. 2024; 23(1):244.

PMID: 39482651 PMC: 11526716. DOI: 10.1186/s12943-024-02163-z.

Vancomycin and nisin-modified magnetic FeO@SiO nanostructures coated with chitosan to enhance antibacterial efficiency against methicillin resistant Staphylococcus aureus (MRSA) infection in a murine superficial wound model.

Nasaj M, Farmany A, Shokoohizadeh L, Jalilian F, Mahjoub R, Roshanaei G BMC Chem. 2024; 18(1):43.

PMID: 38395982 PMC: 10893753. DOI: 10.1186/s13065-024-01129-y.

References

Strommenger B, Kettlitz C, Werner G, Witte W . Multiplex PCR assay for simultaneous detection of nine clinically relevant antibiotic resistance genes in Staphylococcus aureus. J Clin Microbiol. 2003; 41(9):4089-94. PMC: 193808. DOI: 10.1128/JCM.41.9.4089-4094.2003. View

Horn C, Kielian T . Crosstalk Between and Innate Immunity: Focus on Immunometabolism. Front Immunol. 2021; 11:621750. PMC: 7892349. DOI: 10.3389/fimmu.2020.621750. View

Vairo C, Basas J, Pastor M, Palau M, Gomis X, Almirante B . In vitro and in vivo antimicrobial activity of sodium colistimethate and amikacin-loaded nanostructured lipid carriers (NLC). Nanomedicine. 2020; 29:102259. DOI: 10.1016/j.nano.2020.102259. View

Hiramatsu K, Ito T, Tsubakishita S, Sasaki T, Takeuchi F, Morimoto Y . Genomic Basis for Methicillin Resistance in Staphylococcus aureus. Infect Chemother. 2013; 45(2):117-36. PMC: 3780952. DOI: 10.3947/ic.2013.45.2.117. View

Zhu Y, Wang C, Schwarz S, Liu W, Yang Q, Luan T . Identification of a novel tetracycline resistance gene, tet(63), located on a multiresistance plasmid from Staphylococcus aureus. J Antimicrob Chemother. 2020; 76(3):576-581. DOI: 10.1093/jac/dkaa485. View

Kaur T, Putatunda C, Vyas A, Kumar G . Zinc oxide nanoparticles inhibit bacterial biofilm formation via altering cell membrane permeability. Prep Biochem Biotechnol. 2020; 51(4):309-319. DOI: 10.1080/10826068.2020.1815057. View

Piddock L . Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev. 2006; 19(2):382-402. PMC: 1471989. DOI: 10.1128/CMR.19.2.382-402.2006. View

Jung W, Koo H, Kim K, Shin S, Kim S, Park Y . Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Appl Environ Microbiol. 2008; 74(7):2171-8. PMC: 2292600. DOI: 10.1128/AEM.02001-07. View

Ferreira M, Ogren M, Dias J, Silva M, Gil S, Tavares L . Liposomes as Antibiotic Delivery Systems: A Promising Nanotechnological Strategy against Antimicrobial Resistance. Molecules. 2021; 26(7). PMC: 8038399. DOI: 10.3390/molecules26072047. View

10.

Briones E, Colino C, Lanao J . Delivery systems to increase the selectivity of antibiotics in phagocytic cells. J Control Release. 2007; 125(3):210-27. DOI: 10.1016/j.jconrel.2007.10.027. View

11.

Grande F, Tucci P . Titanium Dioxide Nanoparticles: a Risk for Human Health?. Mini Rev Med Chem. 2016; 16(9):762-9. DOI: 10.2174/1389557516666160321114341. View

12.

Gao W, Zhang L . Nanomaterials arising amid antibiotic resistance. Nat Rev Microbiol. 2020; 19(1):5-6. PMC: 7538279. DOI: 10.1038/s41579-020-00469-5. View

13.

Gaupp R, Lei S, Reed J, Peisker H, Boyle-Vavra S, Bayer A . Staphylococcus aureus metabolic adaptations during the transition from a daptomycin susceptibility phenotype to a daptomycin nonsusceptibility phenotype. Antimicrob Agents Chemother. 2015; 59(7):4226-38. PMC: 4468685. DOI: 10.1128/AAC.00160-15. View

14.

Feng X, Liu B, Li J, Liu X . Advances in coupling microfluidic chips to mass spectrometry. Mass Spectrom Rev. 2014; 34(5):535-57. DOI: 10.1002/mas.21417. View

15.

Pelgrift R, Friedman A . Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. 2013; 65(13-14):1803-15. DOI: 10.1016/j.addr.2013.07.011. View

16.

Yung C, Fiering J, Mueller A, Ingber D . Micromagnetic-microfluidic blood cleansing device. Lab Chip. 2009; 9(9):1171-7. DOI: 10.1039/b816986a. View

17.

Cortesi R, Valacchi G, Muresan X, Drechsler M, Contado C, Esposito E . Nanostructured lipid carriers (NLC) for the delivery of natural molecules with antimicrobial activity: production, characterisation and in vitro studies. J Microencapsul. 2017; 34(1):63-72. DOI: 10.1080/02652048.2017.1284276. View

18.

Xie Y, He Y, Irwin P, Jin T, Shi X . Antibacterial activity and mechanism of action of zinc oxide nanoparticles against Campylobacter jejuni. Appl Environ Microbiol. 2011; 77(7):2325-31. PMC: 3067441. DOI: 10.1128/AEM.02149-10. View

19.

Shrestha J, Ryan S, Mills O, Zhand S, Razavi Bazaz S, Hansbro P . A 3D-printed microfluidic platform for simulating the effects of CPAP on the nasal epithelium. Biofabrication. 2021; 13(3). DOI: 10.1088/1758-5090/abe4c1. View

20.

Boedicker J, Li L, Kline T, Ismagilov R . Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics. Lab Chip. 2008; 8(8):1265-72. PMC: 2612531. DOI: 10.1039/b804911d. View