Specific Focus on Antifungal Peptides Against Azole Resistant : Current Status, Challenges, and Future Perspectives

Overview

Journal J Fungi (Basel)

Date 2023 Jan 21

PMID 36675863

Authors

Dilan Andres Pimienta

Freiser Eceomo Cruz Mosquera

Isabella Palacios Velasco

Maria Giraldo Rodas

Jose Onate-Garzon

Yamil Liscano

Affiliations

Soon will be listed here.

Abstract

The prevalence of fungal infections is increasing worldwide, especially that of aspergillosis, which previously only affected people with immunosuppression. can cause allergic bronchopulmonary aspergillosis and endangers public health due to resistance to azole-type antimycotics such as fluconazole. Antifungal peptides are viable alternatives that combat infection by forming pores in membranes through electrostatic interactions with the phospholipids as well as cell death to peptides that inhibit protein synthesis and inhibit cell replication. Engineering antifungal peptides with nanotechnology can enhance the efficacy of these therapeutics at lower doses and reduce immune responses. This manuscript explains how antifungal peptides combat antifungal-resistant aspergillosis and also how rational peptide design with nanotechnology and artificial intelligence can engineer peptides to be a feasible antifungal alternative.

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