Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring

Overview

Journal Toxics

Date 2022 Mar 24

PMID 35324763

Authors

Narimane Djekkoun

Flore Depeint

Marion Guibourdenche

Hiba El Khayat El Sabbouri

Aurelie Corona

Larbi Rhazi

Jerome Gay-Queheillard

Leila Rouabah

Farida Hamdad

Veronique Bach

Moncef Benkhalifa

Hafida Khorsi-Cauet

Affiliations

Soon will be listed here.

Abstract

An increasing burden of evidence is pointing toward pesticides as risk factors for chronic disorders such as obesity and type 2 diabetes, leading to metabolic syndrome. Our objective was to assess the impact of chlorpyrifos (CPF) on metabolic and bacteriologic markers. Female rats were exposed before and during gestation and during lactation to CPF (1 mg/kg/day). Outcomes such as weight, glucose and lipid profiles, as well as disturbances in selected gut bacterial levels, were measured in both the dams (at the end of the lactation period) and in their female offspring at early adulthood (60 days of age). The results show that the weight of CPF dams were lower compared to the other groups, accompanied by an imbalance in blood glucose and lipid markers, and selected gut bacteria. Intra-uterine growth retardation, as well as metabolic disturbances and perturbation of selected gut bacteria, were also observed in their offspring, indicating both a direct effect on the dams and an indirect effect of CPF on the female offspring. Co-treatment with inulin (a prebiotic) prevented some of the outcomes of the pesticide. Further investigations could help better understand if those perturbations mimic or potentiate nutritional risk factors for metabolic syndrome through high fat diet.

Citing Articles

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High-Fat Diet Aggravates the Disorder of Glucose Metabolism Caused by Chlorpyrifos Exposure in Experimental Rats.

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Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics.

Djekkoun N, Depeint F, Guibourdenche M, Sabbouri H, Corona A, Rhazi L Eur J Nutr. 2022; 62(3):1253-1265.

PMID: 36510012 DOI: 10.1007/s00394-022-03063-y.

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