Methods of Sentinel Lymph Node Detection and Management in Urinary Bladder Cancer-A Narrative Review

Overview

Journal Curr Oncol

Publisher MDPI

Specialty Oncology

Date 2022 Mar 24

PMID 35323314

Authors

Ankit Sinha

Alexander West

John Hayes

Jeremy Teoh

Karel Decaestecker

Nikhil Vasdev

Affiliations

Soon will be listed here.

Abstract

Introduction: Detection of lymph node status in bladder cancer significantly impacts clinical decisions regarding its management. There is a wide range of detection modalities for this task, including lymphoscintigraphy, computed tomography, magnetic resonance imaging, single-photon emission computed tomography, positron emission tomography, and fluoroscopy. We aimed to study the pre- and intraoperative detection modalities of sentinel lymph nodes in urinary bladder cancer.

Method: This narrative review was performed by searching the PubMed and EMBASE libraries using the following search terms: ("Transitional cell carcinoma of the bladder" OR "urothelial cancer" OR "urinary bladder cancer" OR "bladder cancer") AND (("sentinel lymph node") OR ("lymphatic mapping") OR ("lymphoscintigraphy") OR ("lymphangiography") OR ("lymph node metastases")). Studies analysing the effectiveness and outcomes of sentinel lymph node detection in bladder cancer were included, while non-English language, duplicates, and non-article studies were excluded. After analysing the libraries and a further manual search of bibliographies, 31 studies were included in this paper. We followed the RAMESES publication standard for narrative reviews to produce this paper.

Results: Of the 31 studies included, 7 studies included multiple detection methods; 5 studies included lymphoscintigraphy; 5 studies included computed tomography and/or single-photon emission computed tomography; 5 studies included fluoroscopy; 4 studies included magnetic resonance imaging; and 5 studies included positron emission tomography.

Discussion: Anatomical, radioactive, and functional detection modalities have been studied independently and in combination. The consensus is that preoperative detection with imaging helps guide surgical management and intraoperative detection methods help capture any lymph nodes that may have been missed. Each of these types of detection represent their own set of benefits and drawbacks, but there is currently limited evidence to support any change in overall practice to replace conventional staging.

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References

Abdollahi A, Jangjoo A, Kakhki V, Zakavi S, Memar B, Naser Forghani M . Factors affecting sentinel lymph node detection failure in breast cancer patients using intradermal injection of the tracer. Rev Esp Med Nucl. 2009; 29(2):73-7. DOI: 10.1016/j.remn.2009.10.001. View

Jewell E, Huang J, Abu-Rustum N, Gardner G, Brown C, Sonoda Y . Detection of sentinel lymph nodes in minimally invasive surgery using indocyanine green and near-infrared fluorescence imaging for uterine and cervical malignancies. Gynecol Oncol. 2014; 133(2):274-7. PMC: 5715808. DOI: 10.1016/j.ygyno.2014.02.028. View

Knapp D, Adams L, Degrand A, Niles J, Ramos-Vara J, Weil A . Sentinel lymph node mapping of invasive urinary bladder cancer in animal models using invisible light. Eur Urol. 2007; 52(6):1700-8. PMC: 2385787. DOI: 10.1016/j.eururo.2007.07.007. View

Wang Y, Wu J, Dai B, Shen Y, Ma C, Ye D . Extended versus non-extended lymphadenectomy during radical cystectomy for patients with bladder cancer: a meta-analysis of the effect on long-term and short-term outcomes. World J Surg Oncol. 2019; 17(1):225. PMC: 6925870. DOI: 10.1186/s12957-019-1759-5. View

Wu S, Zheng J, Li Y, Wu Z, Shi S, Huang M . Development and Validation of an MRI-Based Radiomics Signature for the Preoperative Prediction of Lymph Node Metastasis in Bladder Cancer. EBioMedicine. 2018; 34:76-84. PMC: 6116473. DOI: 10.1016/j.ebiom.2018.07.029. View

Tanis P, Nieweg O, Valdes Olmos R, Rutgers E, Kroon B . History of sentinel node and validation of the technique. Breast Cancer Res. 2001; 3(2):109-12. PMC: 139441. DOI: 10.1186/bcr281. View

Vermeeren L, Olmos R, Meinhardt W, Bex A, van der Poel H, Vogel W . Value of SPECT/CT for detection and anatomic localization of sentinel lymph nodes before laparoscopic sentinel node lymphadenectomy in prostate carcinoma. J Nucl Med. 2009; 50(6):865-70. DOI: 10.2967/jnumed.108.060673. View

Zarifmahmoudi L, Ghorbani H, Sadri K, Tavakkoli M, Keshvari M, Salehi M . Sentinel Node Biopsy in Urothelial Carcinoma of the Bladder: Systematic Review and Meta-Analysis. Urol Int. 2019; 103(4):373-382. DOI: 10.1159/000497310. View

Liedberg F, Chebil G, Davidsson T, Gudjonsson S, Mansson W . Intraoperative sentinel node detection improves nodal staging in invasive bladder cancer. J Urol. 2006; 175(1):84-8. DOI: 10.1016/S0022-5347(05)00066-2. View

10.

Sherif A, Garske U, de la Torre M, Thorn M . Hybrid SPECT-CT: an additional technique for sentinel node detection of patients with invasive bladder cancer. Eur Urol. 2006; 50(1):83-91. DOI: 10.1016/j.eururo.2006.03.002. View

11.

Sawicki S, Kobierski J, Lapinska-Szumczyk S, Lass P, Cytawa W, Bianek-Bodzak A . Comparison of SPECT-CT results and intraoperative detection of sentinel lymph nodes in endometrial cancer. Nucl Med Commun. 2013; 34(6):590-6. DOI: 10.1097/MNM.0b013e328360d8cc. View

12.

Veenstra H, Klop W, Speijers M, Lohuis P, Nieweg O, Hoekstra H . Lymphatic drainage patterns from melanomas on the shoulder or upper trunk to cervical lymph nodes and implications for the extent of neck dissection. Ann Surg Oncol. 2012; 19(12):3906-12. PMC: 3478514. DOI: 10.1245/s10434-012-2387-2. View

13.

Wu S, Zheng J, Li Y, Yu H, Shi S, Xie W . A Radiomics Nomogram for the Preoperative Prediction of Lymph Node Metastasis in Bladder Cancer. Clin Cancer Res. 2017; 23(22):6904-6911. DOI: 10.1158/1078-0432.CCR-17-1510. View

14.

Wong G, Greenhalgh T, Westhorp G, Buckingham J, Pawson R . RAMESES publication standards: meta-narrative reviews. J Adv Nurs. 2013; 69(5):987-1004. DOI: 10.1111/jan.12092. View

15.

Bassi P, Ferrante G, Piazza N, Spinadin R, Carando R, Pappagallo G . Prognostic factors of outcome after radical cystectomy for bladder cancer: a retrospective study of a homogeneous patient cohort. J Urol. 1999; 161(5):1494-7. View

16.

Malkiewicz B, Kielb P, Gurwin A, Knecht K, Wilk K, Dobruch J . The Usefulness of Lymphadenectomy in Bladder Cancer-Current Status. Medicina (Kaunas). 2021; 57(5). PMC: 8145304. DOI: 10.3390/medicina57050415. View

17.

Gillies R, Kinahan P, Hricak H . Radiomics: Images Are More than Pictures, They Are Data. Radiology. 2015; 278(2):563-77. PMC: 4734157. DOI: 10.1148/radiol.2015151169. View

18.

Thill M, Kurylcio A, Welter R, van Haasteren V, Grosse B, Berclaz G . The Central-European SentiMag study: sentinel lymph node biopsy with superparamagnetic iron oxide (SPIO) vs. radioisotope. Breast. 2014; 23(2):175-9. DOI: 10.1016/j.breast.2014.01.004. View

19.

Zarifmahmoudi L, Ghorbani H, Sadeghi R, Sadri K, Tavakkoli M, Keshvari M . Sentinel lymph node biopsy in muscle-invasive bladder cancer: single-center experience. Ann Nucl Med. 2020; 34(10):718-724. DOI: 10.1007/s12149-020-01502-6. View

20.

Paik M, Scolieri M, Brown S, Spirnak J, Resnick M . Limitations of computerized tomography in staging invasive bladder cancer before radical cystectomy. J Urol. 2000; 163(6):1693-6. View