The Usefulness of Lymphadenectomy in Bladder Cancer-Current Status

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2021 Apr 30

PMID 33922894

Citations 8

Authors

Bartosz Malkiewicz

Pawel Kielb

Adam Gurwin

Klaudia Knecht

Karol Wilk

Jakub Dobruch

Romuald Zdrojowy

Affiliations

Soon will be listed here.

Abstract

The purpose of this review is to present the current status of lymph node dissection (LND) during radical cystectomy in patients with bladder cancer (BCa). Despite the growing body of evidence of LND utility at the time of radical cystectomy (RC) in high-risk nonmuscle-invasive and muscle-invasive BCa (MIBC), therapeutic and prognostic value and optimal extent of LND remain unsolved issues. Recently published results of the first prospective, a randomized trial assessing the therapeutic benefit of extended versus limited LND during RC, failed to demonstrate survival improvement with the extended template. Although LND is the most accurate staging procedure, the direct therapeutic effect is still not evident from the current literature, limiting the possibility of establishing clear recommendations. This indicates the need for robust and adequately powered clinical trials.

Citing Articles

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Topography and Lateralization of Nodal Metastases in Muscle-Invasive Bladder Cancer Using Super-Extended Pelvic Lymph Node Dissection with the Sentinel Lymph Node Technique.

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Income Disparities in Survival and Receipt of Neoadjuvant Chemotherapy and Pelvic Lymph Node Dissection for Muscle-Invasive Bladder Cancer.

Antar R, Xu V, Adesanya O, Drouaud A, Longton N, Gordon O Curr Oncol. 2024; 31(5):2566-2581.

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Adequate Pelvic Lymph Node Dissection in Radical Cystectomy in the Era of Neoadjuvant Chemotherapy: A Meta-Analysis and Systematic Review.

Kaczmarek K, Malkiewicz B, Leminski A Cancers (Basel). 2023; 15(16).

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